Antimicrobial activity of diterpene resin acid derivatives

S Savluchinske Feio; B Gigante; J C Roseiro; M J Marcelo-Curto

doi:10.1016/s0167-7012(98)00117-1

Antimicrobial activity of diterpene resin acid derivatives

J Microbiol Methods. 1999 Apr;35(3):201-6. doi: 10.1016/s0167-7012(98)00117-1.

Authors

S Savluchinske Feio¹, B Gigante, J C Roseiro, M J Marcelo-Curto

Affiliation

¹ Instituto Nacional de Engenharia e Tecnologia Industrial, IBQTA, Laboratório de Microbiologia Industrial, Azinhaga dos Lameiros, Lisboa, Portugal.

PMID: 10333071
DOI: 10.1016/s0167-7012(98)00117-1

Abstract

C-13 deisopropylated and/or C-7 oxidized resin acid derivatives were tested against various microorganisms to determine structural features responsible for biological activity and to determine the influence of the C-13 isopropyl group on antimicrobial activity. Test results show that methyl cis and trans 7-oxo-13-deisopropyldehydroabietate and a mixture of both isomers exhibited activity against fungi and bacteria.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Abietanes*
Anti-Bacterial Agents
Anti-Infective Agents / pharmacology*
Antifungal Agents / pharmacology
Bacteria / drug effects*
Diterpenes / chemistry
Diterpenes / pharmacology*
Fungi / drug effects*
Gram-Negative Bacteria / drug effects
Gram-Positive Bacteria / drug effects
Microbial Sensitivity Tests
Structure-Activity Relationship

Substances

Abietanes
Anti-Bacterial Agents
Anti-Infective Agents
Antifungal Agents
Diterpenes
dehydroabietic acid