A case of postoperative rhabdomyolysis following radical prostatectomy for prostate cancer is reported. A 60-year-old man was referred to our hospital because of an elevation of prostate specific antigen detected by the health checkup system. Sextant biopsy for the prostate revealed moderately differentiated adenocarcinoma. Radical prostatectomy was performed after hormonal therapy for 10 months. Two to three days after surgery, the patient complained of a feeling of listlessness. Serum levels of creatine phosphokinase were elevated to 6,584 IU/ml and creatinine slightly elevated to 1.6 mg/dl. Symptoms and laboratory findings improved after sufficient fluid infusion and injection of furosemide. To our knowledge, this is only the third case report in the world literature of postoperative rhabdomyolysis after urological surgery.