[-Skin eruption after the first dose of antitubercular quadri-therapy: consideration of pyrazinamide-]

Abstract

We report a rash after the first dose of antituberculosis polytherapy which raises questions concerning procedures to be followed.

Case report: An 8-year-old child presented with a pruritic rash 1.5 hours after the first dose of isoniazide, rifampicine, pyrazinamide and ethambutol was simultaneously administered, which did not recur after successive re-administration of isoniazide and rifampicine. Pyrazinamide, which was re-administered last, induced a recurrence. Slower pyrazinamide re-administration allowed continuation of treatment.

Conclusion: A protocol for re-administration of the four drugs is suggested.