Prostanoids and related compounds. VII. Synthesis and inhibitory activity of 1-isoindolinone derivatives possessing inhibitory activity against thromboxane A2 analog (U-46619)-induced vasoconstriction

Y Kato; M Takemoto; K Achiwa

doi:10.1248/cpb.47.529

Prostanoids and related compounds. VII. Synthesis and inhibitory activity of 1-isoindolinone derivatives possessing inhibitory activity against thromboxane A2 analog (U-46619)-induced vasoconstriction

Chem Pharm Bull (Tokyo). 1999 Apr;47(4):529-35. doi: 10.1248/cpb.47.529.

Authors

Y Kato¹, M Takemoto, K Achiwa

Affiliation

¹ School of Pharmaceutical Sciences, University of Shizuoka, Japan.

PMID: 10319431
DOI: 10.1248/cpb.47.529

Abstract

We have synthesized a series of novel 1-isoindolinone derivatives, which inhibited the contraction of pig coronary artery induced by U-46619, a thromboxane A2 analog.

MeSH terms

15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid / antagonists & inhibitors*
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid / pharmacology
Animals
Coronary Vessels / drug effects
Indoles / chemical synthesis*
Indoles / pharmacology*
Nuclear Magnetic Resonance, Biomolecular
Prostaglandins / chemical synthesis*
Prostaglandins / pharmacology*
Structure-Activity Relationship
Swine
Vasoconstrictor Agents / antagonists & inhibitors*
Vasoconstrictor Agents / pharmacology

Substances

Indoles
Prostaglandins
Vasoconstrictor Agents
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid