Synthesis of antihypertensive agents via coupling reaction of benzothiazepinone and 1,4-dihydropyridine derivatives

W H Ham; J G Yang; T G Lim; Y H Jung; Y S Chung

doi:10.1007/BF02974235

Synthesis of antihypertensive agents via coupling reaction of benzothiazepinone and 1,4-dihydropyridine derivatives

Arch Pharm Res. 1994 Apr;17(2):119-23. doi: 10.1007/BF02974235.

Authors

W H Ham¹, J G Yang, T G Lim, Y H Jung, Y S Chung

Affiliation

¹ College of Pharmacy, SungKyunKwan University, Suwon, Korea.

PMID: 10319143
DOI: 10.1007/BF02974235

Abstract

The synthesis of 3a, 3b, 7a and 7b from Benzothiazepinone and 1,4-dihyropyridine derivatives is described. Benzothiazepinone and 1,4-dihydropyridine derivatives were prepared according to literature procedure. The key reactions involve esterification and amidation of benzothiazepinone and 1,4-dihydropyridine derivatives.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antihypertensive Agents / chemical synthesis*
Antihypertensive Agents / chemistry
Antihypertensive Agents / pharmacology
Dihydropyridines / chemical synthesis*
Dihydropyridines / chemistry
Dihydropyridines / pharmacology
Magnetic Resonance Spectroscopy
Thiazepines / chemical synthesis*
Thiazepines / chemistry
Thiazepines / pharmacology

Substances

Antihypertensive Agents
Dihydropyridines
Thiazepines
1,4-dihydropyridine