A synthetic study on cyclic phosphate derivatives of seconucleosides as potential antiviral agents (I). Synthesis of 3',5'-cyclic phosphates of 2'-substituted secouridines and secoribavirins

K A Hong; J W Yang; S J Chun; E Y Ha; J H Kim; M W Chun; W K Chung

doi:10.1007/BF02857810

A synthetic study on cyclic phosphate derivatives of seconucleosides as potential antiviral agents (I). Synthesis of 3',5'-cyclic phosphates of 2'-substituted secouridines and secoribavirins

Arch Pharm Res. 1991 Mar;14(1):30-4. doi: 10.1007/BF02857810.

Authors

K A Hong¹, J W Yang, S J Chun, E Y Ha, J H Kim, M W Chun, W K Chung

Affiliation

¹ College of Pharmacy, Seoul National University, Korea.

PMID: 10319117
DOI: 10.1007/BF02857810

Abstract

The synthetic study of 3',5-cyclic phosphates of 2'-substituted 2',3'-secouridines and 2',3'-secoribavirins toward development of new antiviral agents is described. These cyclic phosphates were synthesized from their respective 4-nitrophenyl 3',5'-cyclic phosphate triesters. These triesters were prepared from the corresponding 2'-azido and 2'-bromo 2',3'-seconucleosides.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antiviral Agents / chemical synthesis*
Magnetic Resonance Spectroscopy
Nucleotides, Cyclic / chemical synthesis*

Substances

Antiviral Agents
Nucleotides, Cyclic