N-(4-bromobenzoyl)-S,S-dimethyliminosulfurane, a potent dermal penetration enhancer

L Strekowski; M Henary; N Kim; B B Michniak

doi:10.1016/s0960-894x(99)00131-6

N-(4-bromobenzoyl)-S,S-dimethyliminosulfurane, a potent dermal penetration enhancer

Bioorg Med Chem Lett. 1999 Apr 5;9(7):1033-4. doi: 10.1016/s0960-894x(99)00131-6.

Authors

L Strekowski¹, M Henary, N Kim, B B Michniak

Affiliation

¹ Department of Chemistry, Georgia State University, Atlanta 30303, USA.

PMID: 10230634
DOI: 10.1016/s0960-894x(99)00131-6

Abstract

N-Aroyl-, N-Arylsulfonyl-, and N-Aryl-S,S-dimethyliminosulfuranes have been synthesized and evaluated as potential dermal penetration enhancers. The title compound and Azone exhibit similar activities for permeation of hydrocortisone through hairless mouse skin.

MeSH terms

Animals
Mice
Mice, Hairless
Models, Biological
Skin Absorption / drug effects*
Sulfur Compounds / chemical synthesis
Sulfur Compounds / pharmacology*

Substances

N-(4-bromobenzoyl)-S,S-dimethyliminosulfurane
Sulfur Compounds