Synthesis and biological studies of catechol ether type derivatives as potential phosphodiesterase (PDE) IV inhibitors

C K Rhee; J H Kim; B C Suh; M X Xiang; Y S Youn; W Y Bang; E Kim; J K Shin; Y Lee

doi:10.1007/BF02976547

Synthesis and biological studies of catechol ether type derivatives as potential phosphodiesterase (PDE) IV inhibitors

Arch Pharm Res. 1999 Apr;22(2):202-7. doi: 10.1007/BF02976547.

Authors

C K Rhee¹, J H Kim, B C Suh, M X Xiang, Y S Youn, W Y Bang, E Kim, J K Shin, Y Lee

Affiliation

¹ Department of Medicinal Chemistry, Cheil Jedang Corp., Kyonggi-Do, Korea. ckrhee@www.cheiljedang.com

PMID: 10230513
DOI: 10.1007/BF02976547

Abstract

New series of catechol ether type derivatives 5, 6 have been synthesized and applied to biological tests. Even though it is a preliminary data, some of our target molecules show the promising result against PDE IV inhibition. SAR and biological studies with synthetic compounds will be discussed in detail.

MeSH terms

3',5'-Cyclic-AMP Phosphodiesterases / antagonists & inhibitors*
Animals
Cyclic Nucleotide Phosphodiesterases, Type 4
Guinea Pigs
Male
Phosphodiesterase Inhibitors / chemical synthesis*
Phosphodiesterase Inhibitors / pharmacology
Rats
Rats, Sprague-Dawley
Structure-Activity Relationship

Substances

Phosphodiesterase Inhibitors
3',5'-Cyclic-AMP Phosphodiesterases
Cyclic Nucleotide Phosphodiesterases, Type 4