Complete histological regression of Kaposi's sarcoma following treatment with protease inhibitors despite persistence of HHV-8 in lesions

Scand J Infect Dis. 1998;30(6):613-5. doi: 10.1080/00365549850161205.

Abstract

There is no current curative treatment for HIV-related Kaposi's sarcoma. The identification of human herpesvirus-8 as a possible aetiological agent suggests potential efficacy of anti-viral agents. We report here on the complete histological remission of Kaposi's sarcoma following treatment with protease inhibitors, even in patients with limited virological response and persistence of HHV-8.

Publication types

  • Case Reports

MeSH terms

  • Acyclovir / analogs & derivatives*
  • Acyclovir / therapeutic use
  • HIV Protease Inhibitors / therapeutic use*
  • Herpesvirus 8, Human / isolation & purification*
  • Humans
  • Sarcoma, Kaposi / drug therapy*
  • Sarcoma, Kaposi / pathology
  • Valacyclovir
  • Valine / analogs & derivatives*
  • Valine / therapeutic use

Substances

  • HIV Protease Inhibitors
  • Valine
  • Valacyclovir
  • Acyclovir