Abstract
We studied the role of endogenous acetylcholine (Ach) in corticostriatal long-term potentiation (LTP). The muscarinic receptor antagonists scopolamine and pirenzepine fully prevented the induction of LTP suggesting that the activation of M1-like muscarinic receptors is a crucial event in the conditioning phase of this form of synaptic plasticity.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Acetylcholine / physiology*
-
Animals
-
Cerebral Cortex / physiology*
-
Corpus Striatum / physiology*
-
Long-Term Potentiation / drug effects
-
Long-Term Potentiation / physiology*
-
Male
-
Muscarinic Antagonists / pharmacology
-
Neuronal Plasticity
-
Neurons / drug effects
-
Neurons / physiology*
-
Pirenzepine / pharmacology*
-
Rats
-
Rats, Wistar
-
Receptor, Muscarinic M1
-
Receptors, Muscarinic / drug effects
-
Receptors, Muscarinic / physiology*
-
Scopolamine / pharmacology*
-
Synapses / physiology
Substances
-
Muscarinic Antagonists
-
Receptor, Muscarinic M1
-
Receptors, Muscarinic
-
Pirenzepine
-
Scopolamine
-
Acetylcholine