Activation of M1-like muscarinic receptors is required for the induction of corticostriatal LTP

Neuropharmacology. 1999 Feb;38(2):323-6. doi: 10.1016/s0028-3908(98)00199-3.

Abstract

We studied the role of endogenous acetylcholine (Ach) in corticostriatal long-term potentiation (LTP). The muscarinic receptor antagonists scopolamine and pirenzepine fully prevented the induction of LTP suggesting that the activation of M1-like muscarinic receptors is a crucial event in the conditioning phase of this form of synaptic plasticity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholine / physiology*
  • Animals
  • Cerebral Cortex / physiology*
  • Corpus Striatum / physiology*
  • Long-Term Potentiation / drug effects
  • Long-Term Potentiation / physiology*
  • Male
  • Muscarinic Antagonists / pharmacology
  • Neuronal Plasticity
  • Neurons / drug effects
  • Neurons / physiology*
  • Pirenzepine / pharmacology*
  • Rats
  • Rats, Wistar
  • Receptor, Muscarinic M1
  • Receptors, Muscarinic / drug effects
  • Receptors, Muscarinic / physiology*
  • Scopolamine / pharmacology*
  • Synapses / physiology

Substances

  • Muscarinic Antagonists
  • Receptor, Muscarinic M1
  • Receptors, Muscarinic
  • Pirenzepine
  • Scopolamine
  • Acetylcholine