HIV-1 attachment: another look

Trends Microbiol. 1999 Apr;7(4):144-9. doi: 10.1016/s0966-842x(99)01474-2.

Abstract

HIV-1 attachment to host cells is generally considered to take place via high-affinity binding between CD4 and gp120. However, the binding of virion-associated gp120 to cellular CD4 is often weak, and most cell types that are permissive for HIV-1 infection express little CD4. Thus, other interactions between the virion and the cell surface could dominate the attachment process.

Publication types

  • Review

MeSH terms

  • CD4 Antigens / metabolism
  • Cell Adhesion Molecules / metabolism
  • HIV Envelope Protein gp120 / metabolism*
  • HIV Infections / virology
  • HIV-1 / metabolism*
  • HIV-1 / pathogenicity*
  • Heparan Sulfate Proteoglycans / metabolism
  • Humans
  • Receptors, CCR5 / metabolism
  • Receptors, CXCR4 / metabolism
  • Receptors, Cell Surface / metabolism*

Substances

  • CD4 Antigens
  • Cell Adhesion Molecules
  • HIV Envelope Protein gp120
  • Heparan Sulfate Proteoglycans
  • Receptors, CCR5
  • Receptors, CXCR4
  • Receptors, Cell Surface