Abstract
HIV-1 attachment to host cells is generally considered to take place via high-affinity binding between CD4 and gp120. However, the binding of virion-associated gp120 to cellular CD4 is often weak, and most cell types that are permissive for HIV-1 infection express little CD4. Thus, other interactions between the virion and the cell surface could dominate the attachment process.
MeSH terms
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CD4 Antigens / metabolism
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Cell Adhesion Molecules / metabolism
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HIV Envelope Protein gp120 / metabolism*
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HIV Infections / virology
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HIV-1 / metabolism*
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HIV-1 / pathogenicity*
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Heparan Sulfate Proteoglycans / metabolism
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Humans
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Receptors, CCR5 / metabolism
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Receptors, CXCR4 / metabolism
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Receptors, Cell Surface / metabolism*
Substances
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CD4 Antigens
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Cell Adhesion Molecules
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HIV Envelope Protein gp120
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Heparan Sulfate Proteoglycans
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Receptors, CCR5
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Receptors, CXCR4
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Receptors, Cell Surface