Artoindonesianins A and B, two new prenylated flavones from the root of Artocarpus champeden

E H Hakim; A Fahriyati; M S Kau; S A Achmad; L Makmur; E L Ghisalberti; T Nomura

doi:10.1021/np980279l

Artoindonesianins A and B, two new prenylated flavones from the root of Artocarpus champeden

J Nat Prod. 1999 Apr;62(4):613-5. doi: 10.1021/np980279l.

Authors

E H Hakim¹, A Fahriyati, M S Kau, S A Achmad, L Makmur, E L Ghisalberti, T Nomura

Affiliation

¹ Department of Chemistry, Institut Teknologi Bandung, Jalan Ganeca 10, Bandung 40132, Indonesia.

PMID: 10217722
DOI: 10.1021/np980279l

Abstract

Two new prenylated flavones, named artoindonesianin A (1) and artoindonesianin B (2), were isolated from the root of Artocarpus champeden, together with a known prenylated flavone, artonin A. The structures of artoindonesianins A and B were determined on the basis of spectral evidence (MS, 1H and 13C NMR) and by comparison with known related compounds. Compounds 1 and 2 exhibited cytotoxic activity against murine leukemia (P-388) cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology
Drug Screening Assays, Antitumor
Flavonoids / isolation & purification
Flavonoids / pharmacology*
Indonesia
Leukemia P388 / pathology
Magnetic Resonance Spectroscopy
Mice
Plant Roots / chemistry
Plants, Medicinal / chemistry*
Spectrometry, Mass, Fast Atom Bombardment
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Tumor Cells, Cultured

Substances

Antineoplastic Agents, Phytogenic
Flavonoids
artoindonesianin A
artoindonesianin B