Biophysical and biochemical properties of oligodeoxy-nucleotides containing 4'-C- and 5'-C-substituted thymidines

G Wang; P J Middleton; C Lin; Z Pietrzkowski

doi:10.1016/s0960-894x(99)00103-1

Biophysical and biochemical properties of oligodeoxy-nucleotides containing 4'-C- and 5'-C-substituted thymidines

Bioorg Med Chem Lett. 1999 Mar 22;9(6):885-90. doi: 10.1016/s0960-894x(99)00103-1.

Authors

G Wang¹, P J Middleton, C Lin, Z Pietrzkowski

Affiliation

¹ Research Department, ICN Pharmaceuticals, Inc., Costa Mesa, CA 92626, USA.

PMID: 10206555
DOI: 10.1016/s0960-894x(99)00103-1

Abstract

We have previously reported oligodeoxynucleotides (ODNs) containing 4'-C- and 5'-C-substituted thymidines, which demonstrated certain favorable biophysical and biochemical properties. In this communication, the hybridization and nuclease stability data of the ODNs along with their capability to induce RNase H activity are presented.

MeSH terms

Antigens, CD / metabolism
Humans
Kinetics
Models, Chemical
Oligonucleotides / chemical synthesis
Oligonucleotides / chemistry*
Receptors, Interleukin / metabolism
Receptors, Interleukin-8A
Ribonuclease H / metabolism
Thymidine / chemistry*

Substances

Antigens, CD
Oligonucleotides
Receptors, Interleukin
Receptors, Interleukin-8A
Ribonuclease H
Thymidine