Second generation of the automated Cobas Amplicor HCV assay improves sensitivity of hepatitis C virus RNA detection and yields results that are more clinically relevant

A Doglio; C Laffont; F X Caroli-Bosc; P Rochet; J Lefebvre

doi:10.1128/JCM.37.5.1567-1569.1999

Second generation of the automated Cobas Amplicor HCV assay improves sensitivity of hepatitis C virus RNA detection and yields results that are more clinically relevant

J Clin Microbiol. 1999 May;37(5):1567-9. doi: 10.1128/JCM.37.5.1567-1569.1999.

Authors

A Doglio¹, C Laffont, F X Caroli-Bosc, P Rochet, J Lefebvre

Affiliation

¹ Laboratoire de Virologie, Faculté de Médecine, 06107 Nice, France. doglio@unice.fr

Abstract

The first and second generations of the Cobas Amplicor HCV assay were compared among patients at risk of hepatitis C virus (HCV) infection. The second-generation test was found to be of greater sensitivity and of good specificity among clinical specimens containing HCV RNA of different genotypes. Finally, this new test is shown to predict the outcome of interferon therapy better.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Hepacivirus / genetics*
Hepatitis C / therapy
Humans
Interferons / therapeutic use
RNA, Viral / analysis*
Sensitivity and Specificity

Substances

RNA, Viral
Interferons