Antimalarial activity of 3-hydroxyalkyl-2-methylene-propionic acid derivatives

M K Kundu; M K Kundu; N Sundar; S K Kumar; S V Bhat; S Biswas; N Valecha

doi:10.1016/s0960-894x(99)00057-8

Antimalarial activity of 3-hydroxyalkyl-2-methylene-propionic acid derivatives

Bioorg Med Chem Lett. 1999 Mar 8;9(5):731-6. doi: 10.1016/s0960-894x(99)00057-8.

Authors

M K Kundu¹, M K Kundu, N Sundar, S K Kumar, S V Bhat, S Biswas, N Valecha

Affiliation

¹ Department of Chemistry, Indian Institute of Technology, Powai, Bombay.

PMID: 10201838
DOI: 10.1016/s0960-894x(99)00057-8

Abstract

Several Baylis-Hillman adducts and their derivatives were synthesized and evaluated as targeted potential anti-malarials. The compounds 4, 7 and 9 were found to have highest potency against P. falciparum in vitro. The in vivo test result of compound 4 and 9 against P. berghei demonstrated activity at 80 mg/Kg dose level.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antimalarials / chemical synthesis
Antimalarials / chemistry
Antimalarials / pharmacology*
Chloroquine / pharmacology
Drug Evaluation, Preclinical
Drug Resistance
Plasmodium berghei / drug effects*
Plasmodium falciparum / drug effects*
Propionates / chemical synthesis
Propionates / chemistry
Propionates / pharmacology*

Substances

Antimalarials
Propionates
Chloroquine