The solution structures of calyculin A and dephosphonocalyculin A by NMR

K E Volter; G K Pierens; R J Quinn; T Wakimoto; S Matsunaga; N Fusetani

doi:10.1016/s0960-894x(99)00066-9

The solution structures of calyculin A and dephosphonocalyculin A by NMR

Bioorg Med Chem Lett. 1999 Mar 8;9(5):717-22. doi: 10.1016/s0960-894x(99)00066-9.

Authors

K E Volter¹, G K Pierens, R J Quinn, T Wakimoto, S Matsunaga, N Fusetani

Affiliation

¹ Queensland Pharmaceutical Research Institute, Griffith University, Nathan, Brisbane, Australia.

PMID: 10201835
DOI: 10.1016/s0960-894x(99)00066-9

Abstract

The NMR solution structure of calyculin A (1) in chloroform exhibits intramolecular interactions, resembling the original crystal structure. In methanol, calyculin A has the hydrogen bonding moieties solvent exposed. Dephosphonocalyculin A in chloroform resembles calyculin A in chloroform and the crystal structure of calyculin A. Dephosphonocalyculin A in methanol resembles calyculin A in methanol.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Magnetic Resonance Spectroscopy
Marine Toxins
Models, Chemical
Oxazoles / chemistry*
Porifera / chemistry
Solutions / chemistry

Substances

Marine Toxins
Oxazoles
Solutions
calyculin A