Abstract
A facile preparation of triacetylated derivative of 2-phenylthioglycoside of N-acetylneuraminic acid (4) was achieved by treatment with lipase PS in vinyl acetate. The major product 4 has a free hydroxyl group at C-7. Results of time-course HPLC analysis indicate that the reactivity of the hydroxyl groups under this condition is in the following order; C-9 > C-4 > C-8 > C-7.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylation
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Catalysis
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Chromatography, High Pressure Liquid
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Lipase / metabolism*
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N-Acetylneuraminic Acid / analogs & derivatives
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N-Acetylneuraminic Acid / chemical synthesis
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N-Acetylneuraminic Acid / metabolism*
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Pseudomonas / enzymology
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Time Factors
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Vinyl Compounds / metabolism
Substances
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Vinyl Compounds
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Lipase
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N-Acetylneuraminic Acid
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vinyl acetate