Interaction between capsaicin and nitrate tolerance in isolated guinea-pig heart

Eur J Pharmacol. 1999 Mar 5;368(2-3):R1-3. doi: 10.1016/s0014-2999(99)00056-4.

Abstract

Capsaicin-induced increases in heart rate and coronary flow were blocked by N(G)-nitro-L-Arg-methyl ester (30 mM) in Langendorff-perfused guinea-pig hearts. Neither heart rate nor coronary flow changed by capsaicin in hearts from animals made tolerant to the hypotensive effect of 30 microg/kg nitroglycerin by the administration of 50 mg/kg nitroglycerin subcutaneously 4 times a day over 3 days. We conclude that the effector function of sensory nerves may deteriorate in nitrate tolerance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arginine / pharmacology
  • Capsaicin / pharmacology*
  • Coronary Circulation / drug effects
  • Drug Interactions
  • Drug Tolerance
  • Enzyme Inhibitors / pharmacology
  • Guinea Pigs
  • Heart / drug effects*
  • Heart / physiology
  • Heart Rate / drug effects
  • In Vitro Techniques
  • Male
  • NG-Nitroarginine Methyl Ester / pharmacology
  • Nitrates / pharmacology*
  • Nitroglycerin / pharmacology
  • Perfusion
  • Vasodilator Agents / pharmacology

Substances

  • Enzyme Inhibitors
  • Nitrates
  • Vasodilator Agents
  • Arginine
  • Nitroglycerin
  • Capsaicin
  • NG-Nitroarginine Methyl Ester