Abstract
Capsaicin-induced increases in heart rate and coronary flow were blocked by N(G)-nitro-L-Arg-methyl ester (30 mM) in Langendorff-perfused guinea-pig hearts. Neither heart rate nor coronary flow changed by capsaicin in hearts from animals made tolerant to the hypotensive effect of 30 microg/kg nitroglycerin by the administration of 50 mg/kg nitroglycerin subcutaneously 4 times a day over 3 days. We conclude that the effector function of sensory nerves may deteriorate in nitrate tolerance.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Arginine / pharmacology
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Capsaicin / pharmacology*
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Coronary Circulation / drug effects
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Drug Interactions
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Drug Tolerance
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Enzyme Inhibitors / pharmacology
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Guinea Pigs
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Heart / drug effects*
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Heart / physiology
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Heart Rate / drug effects
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In Vitro Techniques
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Male
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NG-Nitroarginine Methyl Ester / pharmacology
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Nitrates / pharmacology*
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Nitroglycerin / pharmacology
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Perfusion
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Vasodilator Agents / pharmacology
Substances
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Enzyme Inhibitors
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Nitrates
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Vasodilator Agents
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Arginine
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Nitroglycerin
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Capsaicin
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NG-Nitroarginine Methyl Ester