In 10 rabbits, ablation of the uterine horn endometrium and the fallopian tube was performed with the Nd:YAG laser at a power of 60 W using the touch technique. Eight weeks postsurgery, biopsies of the tissue site were obtained showing that the endometrium and tubal mucosa were completely destroyed. Thirty women were sterilized using a similar technique hysteroscopically. Tubal occlusion was demonstrated by hysterosalpingography in all cases at 3 months postoperatively.