Syntheses and biological activities of bis(3-indolyl)thiazoles, analogues of marine bis(indole)alkaloid nortopsentins

X H Gu; X Z Wan; B Jiang

doi:10.1016/s0960-894x(99)00037-2

Syntheses and biological activities of bis(3-indolyl)thiazoles, analogues of marine bis(indole)alkaloid nortopsentins

Bioorg Med Chem Lett. 1999 Feb 22;9(4):569-72. doi: 10.1016/s0960-894x(99)00037-2.

Authors

X H Gu¹, X Z Wan, B Jiang

Affiliation

¹ Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, P.R. China.

PMID: 10098665
DOI: 10.1016/s0960-894x(99)00037-2

Abstract

The thiazole analogues of the marine bis(indole)alkaloid nortopsentins, 2,4-bis(3-indolyl)thiazoles, were synthesized using Hantzsch reaction between indole-3-thioamides and 3-(alpha-bromoacetyl)indoles as the key step, and these analogues showed potent cytotoxic activities against a variety of human cancer cell lines in vitro.

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Drug Screening Assays, Antitumor
Humans
Structure-Activity Relationship
Thiazoles / chemical synthesis*
Thiazoles / chemistry
Thiazoles / pharmacology*
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Thiazoles