Demographic and behavioral characteristics were modeled for distinguishing Native American drug users from non-Native American drug users in Anchorage, Alaska. Data were collected using a structured interview administered to participants (n = 1,091) who smoked cocaine, injected drugs, or both. Multivariate analyses were performed using logistic regression modeling. Four characteristics distinguish Native Americans (n = 223) from non-Native Americans (n = 868). Native Americans were more likely to have used marijuana at an earlier age and to have less than high school education; they were less likely to have ever used heroin and cocaine together, and to have used a condom during sex. Results are useful for administering interventions, data collection, and targeting hidden populations.