Zelkovamycin, a new cyclic peptide antibiotic from Streptomyces sp. K96-0670. II. Structure elucidation

N Tabata; H Tomoda; H Zhang; R Uchida; S Omura

doi:10.7164/antibiotics.52.34

Zelkovamycin, a new cyclic peptide antibiotic from Streptomyces sp. K96-0670. II. Structure elucidation

J Antibiot (Tokyo). 1999 Jan;52(1):34-9. doi: 10.7164/antibiotics.52.34.

Authors

N Tabata¹, H Tomoda, H Zhang, R Uchida, S Omura

Affiliation

¹ Research Center for Biological Function, The Kitasato Institute and Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.

PMID: 10092195
DOI: 10.7164/antibiotics.52.34

Abstract

The structure of antibiotic zelkovamycin was elucidated as a cyclic peptide comprising glycyl, 2-aminobutanoyl, 2-amino-2-butenoyl, N-methyl glycyl, alanyl, 1,3-thiazoyl, 7-methoxytryptophanyl and 2-methyldehydrothreonyl residues. The sequence of the amino acids was established by spectroscopic studies including 1H-1H COSY, 13C-1H COSY, 13C-1H HMQC, 13C-1H HMBC, 15N-1H HMQC and 15N-1H HMBC NMR experiments.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemistry*
Antimicrobial Cationic Peptides
Magnetic Resonance Spectroscopy
Molecular Structure
Peptides*
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Streptomyces / chemistry*

Substances

Anti-Bacterial Agents
Antimicrobial Cationic Peptides
Peptides
zelkovamycin