Abstract
In higher plants, organogenesis occurs continuously from self-renewing apical meristems. Arabidopsis thaliana plants with loss-of-function mutations in the CLAVATA (CLV1, 2, and 3) genes have enlarged meristems and generate extra floral organs. Genetic analysis indicates that CLV1, which encodes a receptor kinase, acts with CLV3 to control the balance between meristem cell proliferation and differentiation. CLV3 encodes a small, predicted extracellular protein. CLV3 acts nonautonomously in meristems and is expressed at the meristem surface overlying the CLV1 domain. These proteins may act as a ligand-receptor pair in a signal transduction pathway, coordinating growth between adjacent meristematic regions.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Amino Acid Sequence
-
Arabidopsis / cytology*
-
Arabidopsis / genetics
-
Arabidopsis / growth & development
-
Arabidopsis / metabolism
-
Arabidopsis Proteins*
-
Cell Differentiation
-
Cell Division
-
Cloning, Molecular
-
Gene Expression Regulation, Plant
-
Genes, Plant
-
In Situ Hybridization
-
Ligands
-
Meristem / cytology*
-
Meristem / growth & development
-
Meristem / metabolism
-
Molecular Sequence Data
-
Mutation
-
Phenotype
-
Plant Proteins / chemistry
-
Plant Proteins / genetics
-
Plant Proteins / metabolism*
-
Plant Shoots / cytology
-
Protein Serine-Threonine Kinases
-
RNA, Messenger / genetics
-
RNA, Messenger / metabolism
-
RNA, Plant / genetics
-
RNA, Plant / metabolism
-
Receptor Protein-Tyrosine Kinases / genetics
-
Receptor Protein-Tyrosine Kinases / metabolism
-
Recombinant Fusion Proteins / metabolism
-
Signal Transduction*
Substances
-
AT2G27250 protein, Arabidopsis
-
Arabidopsis Proteins
-
Ligands
-
Plant Proteins
-
RNA, Messenger
-
RNA, Plant
-
Recombinant Fusion Proteins
-
Receptor Protein-Tyrosine Kinases
-
CLV1 protein, Arabidopsis
-
Protein Serine-Threonine Kinases