Abstract
Tuberculosis, an ancient disease undergoing recent control by public hygiene and drug therapy, has experienced a recrudescence throughout the world. New and effective therapies are rapidly needed to combat infections caused by these strains. Some new 2-quinoxalinecarbonitriles have been synthesized and tested as antituberculosis agents and interesting results have been obtained from the first screening.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antitubercular Agents / chemical synthesis*
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Antitubercular Agents / chemistry
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Antitubercular Agents / pharmacology*
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Mycobacterium tuberculosis / drug effects
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Quinoxalines / chemical synthesis*
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Quinoxalines / chemistry
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Quinoxalines / pharmacology*
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Rifampin / pharmacology
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Spectrophotometry, Infrared
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Structure-Activity Relationship
Substances
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Antitubercular Agents
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Quinoxalines
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Rifampin