Abstract
Genomic DNAs of 14 mammary tumors were analyzed by Southern blot hybridization using a human c-yes-1 oncogene probe. The amplification was successful in half of the cases (7 adenocarcinomas). The degree of amplification was approximately 4-fold, and a high proportion was seen in malignant tumors. In addition, DNA polymorphism was detected in two adenocarcinomas.
MeSH terms
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Adenocarcinoma / genetics
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Adenocarcinoma / veterinary*
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Animals
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Blotting, Southern / veterinary
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DNA, Neoplasm / analysis
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Dog Diseases / genetics*
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Dogs
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Female
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Gene Amplification*
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Immunohistochemistry
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Mammary Neoplasms, Animal / genetics*
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Proto-Oncogene Proteins / genetics*
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Proto-Oncogene Proteins c-yes
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src-Family Kinases*
Substances
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DNA, Neoplasm
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-yes
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src-Family Kinases