Amplification of the c-yes oncogene in canine mammary tumors

J Vet Med Sci. 1999 Feb;61(2):185-9. doi: 10.1292/jvms.61.185.

Abstract

Genomic DNAs of 14 mammary tumors were analyzed by Southern blot hybridization using a human c-yes-1 oncogene probe. The amplification was successful in half of the cases (7 adenocarcinomas). The degree of amplification was approximately 4-fold, and a high proportion was seen in malignant tumors. In addition, DNA polymorphism was detected in two adenocarcinomas.

MeSH terms

  • Adenocarcinoma / genetics
  • Adenocarcinoma / veterinary*
  • Animals
  • Blotting, Southern / veterinary
  • DNA, Neoplasm / analysis
  • Dog Diseases / genetics*
  • Dogs
  • Female
  • Gene Amplification*
  • Immunohistochemistry
  • Mammary Neoplasms, Animal / genetics*
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogene Proteins c-yes
  • src-Family Kinases*

Substances

  • DNA, Neoplasm
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-yes
  • src-Family Kinases