Abstract
The unique aspects of the biochemistry of trypanosomatids make rational drug design an attractive approach, but targets must be selected carefully. Genetic manipulation provides a valuable means of mimicking loss of function attributable to therapeutic intervention, but caution must be exercised when interpreting such data with respect to target validation.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antiprotozoal Agents / pharmacology*
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Drug Design*
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Gene Targeting
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Genes, Protozoan
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Leishmania / drug effects*
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Leishmania / genetics
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Leishmania / metabolism
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Trypanocidal Agents / pharmacology
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Trypanosoma / drug effects*
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Trypanosoma / genetics
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Trypanosoma / metabolism
Substances
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Antiprotozoal Agents
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Trypanocidal Agents