Repression and activation of muscarinic receptor genes

Life Sci. 1999;64(6-7):495-9. doi: 10.1016/s0024-3205(98)00593-1.

Abstract

The specific cellular response to muscarinic receptor activation is dependent upon appropriate expression of each of the five muscarinic receptor genes by individual cells. Here we summarise recent work describing some of the genomic regulatory elements and transcriptional mechanisms that control expression of the M1 and M4 genes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DNA-Binding Proteins / metabolism
  • Gene Expression Regulation*
  • Promoter Regions, Genetic / genetics
  • Rats
  • Receptor, Muscarinic M1
  • Receptor, Muscarinic M4
  • Receptors, Muscarinic / genetics*
  • Repressor Proteins / metabolism

Substances

  • DNA-Binding Proteins
  • Receptor, Muscarinic M1
  • Receptor, Muscarinic M4
  • Receptors, Muscarinic
  • Repressor Proteins