Abstract
The present study examines the effect of salbutamol, a beta2-adrenoreceptor agonist, on blood ammonia levels during an incremental cycle exercise test in healthy non-asthmatic subjects. Blood ammonia levels were lower after inhalation of 400 mcg of salbutamol than after placebo during submaximal exercise: 33+/-2 micromol x l(-1) v.s. 48+/-9 micromol x l(-1) at 220 W and 39+/-2 micromol x l(-1) v.s. 50+/-4 micromol x l(-1) at 260 W. At peak exercise there were no significant differences. The results suggest that beta2-adrenoreceptors are involved in the regulation of blood ammonia during exercise.
Publication types
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Clinical Trial
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Randomized Controlled Trial
MeSH terms
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Administration, Inhalation
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Adrenergic beta-Agonists / administration & dosage
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Adrenergic beta-Agonists / pharmacology*
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Adult
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Albuterol / administration & dosage
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Albuterol / pharmacology*
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Ammonia / blood*
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Blood Glucose / metabolism
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Double-Blind Method
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Exercise / physiology*
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Exercise Test
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Fatty Acids, Nonesterified / blood
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Heart Rate / physiology
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Humans
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Lactic Acid / blood
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Male
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Oxygen Consumption / physiology
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Respiratory Function Tests
Substances
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Adrenergic beta-Agonists
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Blood Glucose
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Fatty Acids, Nonesterified
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Lactic Acid
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Ammonia
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Albuterol