Phagocytosis and development: back to the future

Curr Opin Immunol. 1999 Feb;11(1):47-52. doi: 10.1016/s0952-7915(99)80009-0.

Abstract

Removal of apoptotic cells and micro-organisms is mediated via phagocytosis. Phagocytes express pattern-recognition receptors (PRRs) that recognize apoptotic-cell-associated membrane patterns (ACAMPs). Similar ACAMPs and PRRs are used by mammals, Caenorhabditis elegans and Drosophila melanogaster. Some PRRs recognize apoptotic cells and micro-organisms, suggesting overlap between these functions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Caenorhabditis elegans / immunology
  • Drosophila melanogaster / immunology
  • Humans
  • Macrophages / immunology
  • Macrophages / metabolism
  • Mammals / growth & development
  • Mammals / immunology
  • Phagocytosis / immunology*
  • Receptors, Immunologic

Substances

  • Receptors, Immunologic