New quinoxaline 1,4-di-N-oxides for treatment of tuberculosis

Arzneimittelforschung. 1999 Jan;49(1):55-9. doi: 10.1055/s-0031-1300359.

Abstract

Some quinoxaline 1,4-di-N-oxides derivatives with very different substituents in 2, 3, 6 and 7 positions have been synthesized in order to obtain new hypoxia selective agents. Some of these products have been tested as antituberculosis agents and very interesting results have been obtained from the first screening.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibiotics, Antitubercular / pharmacology
  • Antitubercular Agents / chemical synthesis*
  • Antitubercular Agents / pharmacology
  • Cyclic N-Oxides / chemical synthesis*
  • Cyclic N-Oxides / pharmacology
  • Microbial Sensitivity Tests
  • Mycobacterium tuberculosis / drug effects*
  • Quinoxalines / chemical synthesis*
  • Quinoxalines / pharmacology
  • Rifampin / pharmacology

Substances

  • Antibiotics, Antitubercular
  • Antitubercular Agents
  • Cyclic N-Oxides
  • Quinoxalines
  • Rifampin