Synthesis of an imidazo[1,2-e]purine-acridine heterodimer for targeting abasic sites in DNA

P Belmont; K Alarcon; M Demeunynck; J Lhomme

doi:10.1016/s0960-894x(98)00703-3

Synthesis of an imidazo[1,2-e]purine-acridine heterodimer for targeting abasic sites in DNA

Bioorg Med Chem Lett. 1999 Jan 18;9(2):233-6. doi: 10.1016/s0960-894x(98)00703-3.

Authors

P Belmont¹, K Alarcon, M Demeunynck, J Lhomme

Affiliation

¹ LEDSS, UMR CNRS 5616/Université J. Fourier, Grenoble, France.

PMID: 10021935
DOI: 10.1016/s0960-894x(98)00703-3

Abstract

Cyclization of 8-bromo-9-alkylaminoethyl-adenine quantitatively affords a substituted imidazo[1,2-e]purine. The corresponding heterodimer, imidazo[1,2-e]purine-acridine, was prepared and its interaction with abasic site containing oligonucleotides was studied.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

DNA / chemistry*
Imidazoles / chemical synthesis*
Imidazoles / chemistry*
Purines / chemical synthesis*
Purines / chemistry
Temperature

Substances

4-amino-6-(((6-chloro-2-methoxyacridin-9-yl)aminopropyl)amino)-7,8-dihydroimidazo(1,2-e)purine
Imidazoles
Purines
DNA