Description of the preparation and composition of a new type of polyvalent vaccine against bradsot, infectious enterotoxemia and malignant edema (necrotic hepatitis) of sheep as well as dysentery of lambs. This vaccine is a formolized polyanatoxin obtained after centrifugation, purification and concentration of the toxins followed by formolization and adsorption on aluminum hydroxyde. The serum antibody titers are much higher than after utilizing the usual vaccines and the period of immunity in the sheep is considerably extended.