A maelstrom of migrating monocytes drives neurodegeneration

Nicole G Coufal; Michelle L Hermiston

doi:10.1016/j.immuni.2023.11.014

A maelstrom of migrating monocytes drives neurodegeneration

Immunity. 2023 Dec 12;56(12):2677-2678. doi: 10.1016/j.immuni.2023.11.014.

Authors

Nicole G Coufal¹, Michelle L Hermiston²

Affiliations

¹ Department of Pediatrics, University of California, San Diego, San Diego, CA, USA.
² Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA. Electronic address: michelle.hermiston@ucsf.edu.

PMID: 38091948
DOI: 10.1016/j.immuni.2023.11.014

Abstract

Neurodegeneration is a devastating complication of Langerhans cell histiocytosis (LCH), but it is not clear how it develops. In this issue of Immunity, Wilk et al. demonstrate that circulating BRAFV600E⁺ myeloid cells damage the blood-brain barrier and infiltrate the brain. Dual inhibition of the MAPK and senescence pathways can block parenchymal injury, providing a potential therapeutic avenue for histiocytic neurodegeneration.

MeSH terms

Blood-Brain Barrier / metabolism
Brain / metabolism
Histiocytosis, Langerhans-Cell* / metabolism
Humans
Monocytes* / metabolism
Myeloid Cells / metabolism
Proto-Oncogene Proteins B-raf / metabolism

Substances

Proto-Oncogene Proteins B-raf