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An evolutionarily conserved ubiquitin ligase drives infection and transmission of flaviviruses.
Wu L, Zhang L, Feng S, Chen L, Lin C, Wang G, Zhu Y, Wang P, Cheng G. Wu L, et al. Proc Natl Acad Sci U S A. 2024 Apr 16;121(16):e2317978121. doi: 10.1073/pnas.2317978121. Epub 2024 Apr 9. Proc Natl Acad Sci U S A. 2024. PMID: 38593069
Mosquito-borne flaviviruses such as dengue (DENV) and Zika (ZIKV) cause hundreds of millions of infections annually. The single-stranded RNA genome of flaviviruses is translated into a polyprotein, which is cleaved equally into individual functional proteins. ...Furthermor …
Mosquito-borne flaviviruses such as dengue (DENV) and Zika (ZIKV) cause hundreds of millions of infections annually. The single-stran …
New perspective of small-molecule antiviral drugs development for RNA viruses.
Li S, Li H, Lian R, Xie J, Feng R. Li S, et al. Virology. 2024 Jun;594:110042. doi: 10.1016/j.virol.2024.110042. Epub 2024 Mar 7. Virology. 2024. PMID: 38492519 Review.
At present, AIDS, viral hepatitis and other viral diseases with high incidence and low cure rate are still spreading around the world. The outbreaks of Ebola, Zika, dengue and in particular of the global pandemic of COVID-19 have presented serious challenges to the global …
At present, AIDS, viral hepatitis and other viral diseases with high incidence and low cure rate are still spreading around the world. The o …
A mosquito salivary protein-driven influx of myeloid cells facilitates flavivirus transmission.
Wang Z, Nie K, Liang Y, Niu J, Yu X, Zhang O, Liu L, Shi X, Wang Y, Feng X, Zhu Y, Wang P, Cheng G. Wang Z, et al. EMBO J. 2024 May;43(9):1690-1721. doi: 10.1038/s44318-024-00056-x. Epub 2024 Feb 20. EMBO J. 2024. PMID: 38378891 Free PMC article.
Here, we show that a female mosquito salivary gland-specific protein, here named A. aegypti Neutrophil Recruitment Protein (AaNRP), facilitates the transmission of Zika and dengue viruses. AaNRP promotes a rapid influx of neutrophils, followed by virus-susceptible m …
Here, we show that a female mosquito salivary gland-specific protein, here named A. aegypti Neutrophil Recruitment Protein (AaNRP), facilita …
Bystander activated CD8(+) T cells mediate neuropathology during viral infection via antigen-independent cytotoxicity.
Balint E, Feng E, Giles EC, Ritchie TM, Qian AS, Vahedi F, Montemarano A, Portillo AL, Monteiro JK, Trigatti BL, Ashkar AA. Balint E, et al. Nat Commun. 2024 Feb 5;15(1):896. doi: 10.1038/s41467-023-44667-0. Nat Commun. 2024. PMID: 38316762 Free PMC article.
Although many viral infections are linked to the development of neurological disorders, the mechanism governing virus-induced neuropathology remains poorly understood, particularly when the virus is not directly neuropathic. Using a mouse model of Zika vir …
Although many viral infections are linked to the development of neurological disorders, the mechanism governing virus-induced neuropa …
Atranorin inhibits Zika virus infection in human glioblastoma cell line SNB-19 via targeting Zika virus envelope protein.
Huang GG, Wang HY, Wang XH, Yang T, Zhang XM, Feng CL, Zhao WM, Tang W. Huang GG, et al. Phytomedicine. 2024 Mar;125:155343. doi: 10.1016/j.phymed.2024.155343. Epub 2024 Jan 8. Phytomedicine. 2024. PMID: 38290230
BACKGROUND: Zika virus (ZIKV) is a single-stranded RNA flavivirus transmitted by mosquitoes. ...RESULTS: Our study showed that atranorin could protect SNB-19 cells from ZIKV infection, as evidenced by inhibited viral protein expression and progeny virus …
BACKGROUND: Zika virus (ZIKV) is a single-stranded RNA flavivirus transmitted by mosquitoes. ...RESULTS: Our study showed that …
Identification of alpha-linolenic acid as a broad-spectrum antiviral against zika, dengue, herpes simplex, influenza virus and SARS-CoV-2 infection.
Feng Y, Yang Y, Zou S, Qiu S, Yang H, Hu Y, Lin G, Yao X, Liu S, Zou M. Feng Y, et al. Antiviral Res. 2023 Aug;216:105666. doi: 10.1016/j.antiviral.2023.105666. Epub 2023 Jul 8. Antiviral Res. 2023. PMID: 37429528
Zika virus (ZIKV) has garnered global attention due to its association with severe congenital defects including microcephaly. ...Further examination revealed that ALA inhibited DENV-2, HSV-1, influenza virus and SARS-CoV-2 infection dose-dependently. A …
Zika virus (ZIKV) has garnered global attention due to its association with severe congenital defects including microcephaly. …
Targeting Type I Interferon Induction and Signaling: How Zika Virus Escapes from Host Innate Immunity.
Hu H, Feng Y, He ML. Hu H, et al. Int J Biol Sci. 2023 Jun 4;19(10):3015-3028. doi: 10.7150/ijbs.83056. eCollection 2023. Int J Biol Sci. 2023. PMID: 37416780 Free PMC article. Review.
Zika virus (ZIKV) infection causes neurological disorders and draws great attention. ZIKV infection can elicit a wide range of immune response. Type I interferons (IFNs) as well as its signaling cascade play crucial role in innate immunity against ZIKV …
Zika virus (ZIKV) infection causes neurological disorders and draws great attention. ZIKV infection can elicit a …
Expanded profiling of Remdesivir as a broad-spectrum antiviral and low potential for interaction with other medications in vitro.
Radoshitzky SR, Iversen P, Lu X, Zou J, Kaptein SJF, Stuthman KS, Van Tongeren SA, Steffens J, Gong R, Truong H, Sapre AA, Yang H, Xie X, Chia JJ, Song ZJ, Leventhal SM, Chan J, Shornikov A, Zhang X, Cowfer D, Yu H, Warren T, Cihlar T, Porter DP, Neyts J, Shi PY, Wells J, Bilello JP, Feng JY. Radoshitzky SR, et al. Sci Rep. 2023 Feb 23;13(1):3131. doi: 10.1038/s41598-023-29517-9. Sci Rep. 2023. PMID: 36823196 Free PMC article.
Using cell-based assays, we show that remdesivir can inhibit infection of flaviviruses (such as dengue 1-4, West Nile, yellow fever, Zika viruses), picornaviruses (such as enterovirus and rhinovirus), and filoviruses (such as various Ebola, Marburg, and Sudan vir …
Using cell-based assays, we show that remdesivir can inhibit infection of flaviviruses (such as dengue 1-4, West Nile, yellow fever, …
NSUN2-mediated M5c methylation of IRF3 mRNA negatively regulates type I interferon responses during various viral infections.
Wang H, Feng J, Zeng C, Liu J, Fu Z, Wang D, Wang Y, Zhang L, Li J, Jiang A, He M, Cao Y, Yan K, Tang H, Guo D, Xu K, Zhou X, Zhou L, Lan K, Zhou Y, Chen Y. Wang H, et al. Emerg Microbes Infect. 2023 Dec;12(1):2178238. doi: 10.1080/22221751.2023.2178238. Emerg Microbes Infect. 2023. PMID: 36748584 Free PMC article.
The highly m(5)C methylated cytosines in IRF3 mRNA were identified, and their mutation enhanced cellular IRF3 mRNA levels. Moreover, infection with Sendai virus (SeV), vesicular stomatitis virus (VSV), herpes simplex virus 1 (HSV-1), or Zika …
The highly m(5)C methylated cytosines in IRF3 mRNA were identified, and their mutation enhanced cellular IRF3 mRNA levels. Moreover, infe …
Predicting the Impact of Climate Change on the Distribution of a Neglected Arboviruses Vector (Armigeres subalbatus) in China.
Wang G, Zhang D, Khan J, Guo J, Feng Q, Sun Y, Li B, Wu Y, Wu Z, Zheng X. Wang G, et al. Trop Med Infect Dis. 2022 Dec 12;7(12):431. doi: 10.3390/tropicalmed7120431. Trop Med Infect Dis. 2022. PMID: 36548686 Free PMC article.
Armigeres subalbatus (Coquillett, 1898), a common and neglected species, is of increasing interest given its potential vector capacity for Zika virus. However, potential distribution patterns and the underlying driving factors of Ar. subalbatus remain unknown. ...
Armigeres subalbatus (Coquillett, 1898), a common and neglected species, is of increasing interest given its potential vector capacity for …
66 results