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Page 1
Molecular mechanisms of MLL-associated leukemia.
Yokoyama A. Yokoyama A. Int J Hematol. 2015 Apr;101(4):352-61. doi: 10.1007/s12185-015-1774-4. Epub 2015 Mar 17. Int J Hematol. 2015. PMID: 25773519 Review.
Gene rearrangements of the mixed lineage leukemia (MLL) gene cause aggressive leukemia. The fusion of MLL and its partner genes generates various MLL fusion genes, and their gene products trigger aberrant self-renewal of hematopoietic progenitors leading to l …
Gene rearrangements of the mixed lineage leukemia (MLL) gene cause aggressive leukemia. The fusion of MLL and its partner gene …
Transcriptional activation by MLL fusion proteins in leukemogenesis.
Yokoyama A. Yokoyama A. Exp Hematol. 2017 Feb;46:21-30. doi: 10.1016/j.exphem.2016.10.014. Epub 2016 Nov 16. Exp Hematol. 2017. PMID: 27865805 Free article. Review.
Chromosomal translocations involving the mixed lineage leukemia (MLL) gene cause aggressive leukemia. Fusion proteins of MLL and a component of the AF4 family/ENL family/P-TEFb complex (AEP) are responsible for two-thirds of MLL-associated leukemia cases. …
Chromosomal translocations involving the mixed lineage leukemia (MLL) gene cause aggressive leukemia. Fusion proteins of MLL a …
HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis.
Takahashi S, Kanai A, Okuda H, Miyamoto R, Komata Y, Kawamura T, Matsui H, Inaba T, Takaori-Kondo A, Yokoyama A. Takahashi S, et al. Elife. 2021 Aug 25;10:e65872. doi: 10.7554/eLife.65872. Elife. 2021. PMID: 34431785 Free PMC article.
Of the many MLL fusions, MLL-ELL particularly depended on the THD2-mediated association with the HBO1 complex for leukemic transformation. ...Moreover, the NUP98-HBO1 fusion protein exerted its oncogenic properties via interaction with MLL but not its intrins …
Of the many MLL fusions, MLL-ELL particularly depended on the THD2-mediated association with the HBO1 complex for leukemic tra …
Role of the MOZ/MLL-mediated transcriptional activation system for self-renewal in normal hematopoiesis and leukemogenesis.
Yokoyama A. Yokoyama A. FEBS J. 2022 Dec;289(24):7987-8002. doi: 10.1111/febs.16180. Epub 2021 Sep 16. FEBS J. 2022. PMID: 34482632 Free PMC article. Review.
Gene rearrangements of MOZ and MLL generate chimeric genes encoding fusion proteins that function as constitutively active forms. ...This review summarizes the functions of the components of the MOZ/MLL-mediated transcriptional activation system and their roles in t …
Gene rearrangements of MOZ and MLL generate chimeric genes encoding fusion proteins that function as constitutively active forms. ... …
The molecular functions of common and atypical MLL fusion protein complexes.
Takahashi S, Yokoyama A. Takahashi S, et al. Biochim Biophys Acta Gene Regul Mech. 2020 Jul;1863(7):194548. doi: 10.1016/j.bbagrm.2020.194548. Epub 2020 Apr 19. Biochim Biophys Acta Gene Regul Mech. 2020. PMID: 32320750 Review.
Mixed-lineage leukemia (MLL) fuses with a variety of partners to produce a functionally altered MLL complex that is not expressed in normal cells, which transforms normal hematopoietic progenitors into leukemia cells. ...It appears that most (if not all) MLL …
Mixed-lineage leukemia (MLL) fuses with a variety of partners to produce a functionally altered MLL complex that is not expres …
Leukemogenesis via aberrant self-renewal by the MLL/AEP-mediated transcriptional activation system.
Yokoyama A. Yokoyama A. Cancer Sci. 2021 Oct;112(10):3935-3944. doi: 10.1111/cas.15054. Epub 2021 Aug 2. Cancer Sci. 2021. PMID: 34251718 Free PMC article. Review.
In leukemia, mutated MLL proteins constitutively activate a broad range of previously transcribed CpG-rich promoters by an MLL-mediated transcriptional activation system. ...MLL recruits p300/CBP through its transcriptional activation domain, which acetylates …
In leukemia, mutated MLL proteins constitutively activate a broad range of previously transcribed CpG-rich promoters by an MLL …
[The mechanism of MLL-rearranged leukemogenesis and its targeted therapies].
Yokoyama A. Yokoyama A. Rinsho Ketsueki. 2021;62(8):988-997. doi: 10.11406/rinketsu.62.988. Rinsho Ketsueki. 2021. PMID: 34497239 Review. Japanese.
Normally, replication of the expression profile only occurs in the hematopoietic stem cells (HSCs). A transactivation system comprised of MLL and AF4/ENL/P-TEFb (AEP) complexes promotes it by reactivating CpG-rich promoters. In the normal hematopoietic development, this sy …
Normally, replication of the expression profile only occurs in the hematopoietic stem cells (HSCs). A transactivation system comprised of …
Activation of CpG-Rich Promoters Mediated by MLL Drives MOZ-Rearranged Leukemia.
Miyamoto R, Okuda H, Kanai A, Takahashi S, Kawamura T, Matsui H, Kitamura T, Kitabayashi I, Inaba T, Yokoyama A. Miyamoto R, et al. Cell Rep. 2020 Sep 29;32(13):108200. doi: 10.1016/j.celrep.2020.108200. Cell Rep. 2020. PMID: 32997997 Free article.
MOZ also targets a broad range of CpG-rich promoters through association with RNAP2 and MLL. Leukemic fusion proteins such as MOZ-TIF2 and MLL-AFX constitutively activate CpG-rich promoters by aberrantly recruiting p300/CBP. Pharmacological inhibition of MLL …
MOZ also targets a broad range of CpG-rich promoters through association with RNAP2 and MLL. Leukemic fusion proteins such as MOZ-TIF …
RNA-binding proteins of KHDRBS and IGF2BP families control the oncogenic activity of MLL-AF4.
Okuda H, Miyamoto R, Takahashi S, Kawamura T, Ichikawa J, Harada I, Tamura T, Yokoyama A. Okuda H, et al. Nat Commun. 2022 Nov 5;13(1):6688. doi: 10.1038/s41467-022-34558-1. Nat Commun. 2022. PMID: 36335100 Free PMC article.
Chromosomal translocation generates the MLL-AF4 fusion gene, which causes acute leukemia of multiple lineages. ...Synonymous mutations disrupting the association of KHDRBSs result in proper translation of MLL-AF4 and leukemic transformation. Consequently, the synony …
Chromosomal translocation generates the MLL-AF4 fusion gene, which causes acute leukemia of multiple lineages. ...Synonymous mutation …
RNA Polymerase II-Dependent Transcription Initiated by Selectivity Factor 1: A Central Mechanism Used by MLL Fusion Proteins in Leukemic Transformation.
Yokoyama A. Yokoyama A. Front Genet. 2019 Jan 14;9:722. doi: 10.3389/fgene.2018.00722. eCollection 2018. Front Genet. 2019. PMID: 30693017 Free PMC article. Review.
In leukemia, AF4 and ENL family genes are frequently rearranged to form chimeric fusion genes with MLL. The resultant MLL fusion genes produce chimeric MLL fusion proteins comprising MLL and AEP components. ...The fusion partner portion, which recruits …
In leukemia, AF4 and ENL family genes are frequently rearranged to form chimeric fusion genes with MLL. The resultant MLL fusi …
37 results