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Quantitative Systems Pharmacology Approaches for Immuno-Oncology: Adding Virtual Patients to the Development Paradigm.
Chelliah V, Lazarou G, Bhatnagar S, Gibbs JP, Nijsen M, Ray A, Stoll B, Thompson RA, Gulati A, Soukharev S, Yamada A, Weddell J, Sayama H, Oishi M, Wittemer-Rump S, Patel C, Niederalt C, Burghaus R, Scheerans C, Lippert J, Kabilan S, Kareva I, Belousova N, Rolfe A, Zutshi A, Chenel M, Venezia F, Fouliard S, Oberwittler H, Scholer-Dahirel A, Lelievre H, Bottino D, Collins SC, Nguyen HQ, Wang H, Yoneyama T, Zhu AZX, van der Graaf PH, Kierzek AM. Chelliah V, et al. Among authors: van der graaf ph. Clin Pharmacol Ther. 2021 Mar;109(3):605-618. doi: 10.1002/cpt.1987. Epub 2020 Aug 14. Clin Pharmacol Ther. 2021. PMID: 32686076 Free PMC article. Review.
Model-based drug development: a rational approach to efficiently accelerate drug development.
Milligan PA, Brown MJ, Marchant B, Martin SW, van der Graaf PH, Benson N, Nucci G, Nichols DJ, Boyd RA, Mandema JW, Krishnaswami S, Zwillich S, Gruben D, Anziano RJ, Stock TC, Lalonde RL. Milligan PA, et al. Among authors: van der graaf ph. Clin Pharmacol Ther. 2013 Jun;93(6):502-14. doi: 10.1038/clpt.2013.54. Epub 2013 Mar 14. Clin Pharmacol Ther. 2013. PMID: 23588322
Mathematical Biology Models of Parkinson's Disease.
Bakshi S, Chelliah V, Chen C, van der Graaf PH. Bakshi S, et al. Among authors: van der graaf ph. CPT Pharmacometrics Syst Pharmacol. 2019 Feb;8(2):77-86. doi: 10.1002/psp4.12362. Epub 2018 Nov 2. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 30358157 Free PMC article. Review.
Best Practices to Maximize the Use and Reuse of Quantitative and Systems Pharmacology Models: Recommendations From the United Kingdom Quantitative and Systems Pharmacology Network.
Cucurull-Sanchez L, Chappell MJ, Chelliah V, Amy Cheung SY, Derks G, Penney M, Phipps A, Malik-Sheriff RS, Timmis J, Tindall MJ, van der Graaf PH, Vicini P, Yates JWT. Cucurull-Sanchez L, et al. Among authors: van der graaf ph. CPT Pharmacometrics Syst Pharmacol. 2019 May;8(5):259-272. doi: 10.1002/psp4.12381. Epub 2019 Mar 22. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 30667172 Free PMC article.
A Quantitative Systems Pharmacology Consortium Approach to Managing Immunogenicity of Therapeutic Proteins.
Kierzek AM, Hickling TP, Figueroa I, Kalvass JC, Nijsen M, Mohan K, Veldman GM, Yamada A, Sayama H, Yokoo S, Gulati A, Dhanikula RS, Gokemeijer J, Leil TA, Thalhauser CJ, Giorgi M, Swat MJ, Chelliah V, Small BG, Benson N, Walker M, Gadkar K, Quarmby V, Deng R, Ferrante A, Dickinson GL, Van Der Walt JS, Zhou L, Chen X, Jones HM, Narula J, Tourdot S, Lavé T, Ribba B, van der Graaf PH. Kierzek AM, et al. Among authors: van der graaf ph, van der walt js. CPT Pharmacometrics Syst Pharmacol. 2019 Nov;8(11):773-776. doi: 10.1002/psp4.12465. Epub 2019 Oct 8. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 31529677 Free PMC article. No abstract available.
Quantitative Systems Pharmacology for Neuroscience Drug Discovery and Development: Current Status, Opportunities, and Challenges.
Geerts H, Wikswo J, van der Graaf PH, Bai JPF, Gaiteri C, Bennett D, Swalley SE, Schuck E, Kaddurah-Daouk R, Tsaioun K, Pelleymounter M. Geerts H, et al. Among authors: van der graaf ph. CPT Pharmacometrics Syst Pharmacol. 2020 Jan;9(1):5-20. doi: 10.1002/psp4.12478. Epub 2019 Nov 24. CPT Pharmacometrics Syst Pharmacol. 2020. PMID: 31674729 Free PMC article.
Immunogenicity in Clinical Practice and Drug Development: When is it Significant?
Shakhnovich V, Meibohm B, Rosenberg A, Kierzek AM, Hasenkamp R, Funk RS, Thalhauser CJ, van der Graaf PH, Wang YC, Hamuro L. Shakhnovich V, et al. Among authors: van der graaf ph. Clin Transl Sci. 2020 Mar;13(2):219-223. doi: 10.1111/cts.12717. Epub 2019 Nov 25. Clin Transl Sci. 2020. PMID: 31762152 Free PMC article. No abstract available.
227 results