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Characterisation of the pharmacodynamic effects of the P2X7 receptor antagonist JNJ-54175446 using an oral dexamphetamine challenge model in healthy males in a randomised, double-blind, placebo-controlled, multiple ascending dose trial.
Recourt K, van der Aart J, Jacobs G, de Kam M, Drevets W, van Nueten L, Kanhai K, Siebenga P, Zuiker R, Ravenstijn P, Timmers M, van Gerven J, de Boer P. Recourt K, et al. Among authors: van der aart j. J Psychopharmacol. 2020 Sep;34(9):1030-1042. doi: 10.1177/0269881120914206. Epub 2020 Apr 4. J Psychopharmacol. 2020. PMID: 32248747 Clinical Trial.
Safety and Pharmacokinetics of HTL0018318, a Novel M1 Receptor Agonist, Given in Combination with Donepezil at Steady State: A Randomized Trial in Healthy Elderly Subjects.
Bakker C, van der Aart J, Labots G, Liptrot J, Cross DM, Klaassen ES, Dickinson S, Tasker T, Groeneveld GJ. Bakker C, et al. Among authors: van der aart j. Drugs R D. 2021 Sep;21(3):295-304. doi: 10.1007/s40268-021-00352-5. Epub 2021 Jun 23. Drugs R D. 2021. PMID: 34164794 Free PMC article. Clinical Trial.
Human Dosimetry of the N-Methyl-d-Aspartate Receptor Ligand 11C-GMOM.
van der Aart J, van der Doef TF, Horstman P, Huisman MC, Schuit RC, van Lingen A, Windhorst AD, van Berckel BNM, Lammertsma AA. van der Aart J, et al. J Nucl Med. 2017 Aug;58(8):1330-1333. doi: 10.2967/jnumed.116.188250. Epub 2017 Feb 9. J Nucl Med. 2017. PMID: 28183990 Free article. Clinical Trial.
Prediction of repeat-dose occupancy from single-dose data: characterisation of the relationship between plasma pharmacokinetics and brain target occupancy.
Abanades S, van der Aart J, Barletta JA, Marzano C, Searle GE, Salinas CA, Ahmad JJ, Reiley RR, Pampols-Maso S, Zamuner S, Cunningham VJ, Rabiner EA, Laruelle MA, Gunn RN. Abanades S, et al. Among authors: van der aart j. J Cereb Blood Flow Metab. 2011 Mar;31(3):944-52. doi: 10.1038/jcbfm.2010.175. Epub 2010 Oct 13. J Cereb Blood Flow Metab. 2011. PMID: 20940733 Free PMC article.
15 results