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Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy.
Grosch M, Schraft L, Chan A, Küchenhoff L, Rapti K, Ferreira AM, Kornienko J, Li S, Radke MH, Krämer C, Clauder-Münster S, Perlas E, Backs J, Gotthardt M, Dieterich C, van den Hoogenhof MMG, Grimm D, Steinmetz LM. Grosch M, et al. Among authors: van den hoogenhof mmg. Nat Commun. 2023 Jun 22;14(1):3714. doi: 10.1038/s41467-023-39352-1. Nat Commun. 2023. PMID: 37349314 Free PMC article.
New Insights in RBM20 Cardiomyopathy.
Lennermann D, Backs J, van den Hoogenhof MMG. Lennermann D, et al. Among authors: van den hoogenhof mmg. Curr Heart Fail Rep. 2020 Oct;17(5):234-246. doi: 10.1007/s11897-020-00475-x. Curr Heart Fail Rep. 2020. PMID: 32789749 Free PMC article. Review.
Deep phenotyping of two preclinical mouse models and a cohort of RBM20 mutation carriers reveals no sex-dependent disease severity in RBM20 cardiomyopathy.
Lennermann DC, Pepin ME, Grosch M, Konrad L, Kemmling E, Hartmann J, Nolte JL, Clauder-Münster S, Kayvanpour E, Sedaghat-Hamedani F, Haas J, Meder B, van den Boogaard M, Amin AS, Dewenter M, Krüger M, Steinmetz LM, Backs J, van den Hoogenhof MMG. Lennermann DC, et al. Among authors: van den hoogenhof mmg. Am J Physiol Heart Circ Physiol. 2022 Dec 1;323(6):H1296-H1310. doi: 10.1152/ajpheart.00328.2022. Epub 2022 Nov 11. Am J Physiol Heart Circ Physiol. 2022. PMID: 36367695 Free article.
Physiological and unappreciated roles of CaMKII in the heart.
Beckendorf J, van den Hoogenhof MMG, Backs J. Beckendorf J, et al. Among authors: van den hoogenhof mmg. Basic Res Cardiol. 2018 Jun 15;113(4):29. doi: 10.1007/s00395-018-0688-8. Basic Res Cardiol. 2018. PMID: 29905892 Free PMC article. Review.
CaMKIIδ Splice Variants in the Healthy and Diseased Heart.
Duran J, Nickel L, Estrada M, Backs J, van den Hoogenhof MMG. Duran J, et al. Among authors: van den hoogenhof mmg. Front Cell Dev Biol. 2021 Mar 11;9:644630. doi: 10.3389/fcell.2021.644630. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 33777949 Free PMC article. Review.
A mutation in the glutamate-rich region of RNA-binding motif protein 20 causes dilated cardiomyopathy through missplicing of titin and impaired Frank-Starling mechanism.
Beqqali A, Bollen IA, Rasmussen TB, van den Hoogenhof MM, van Deutekom HW, Schafer S, Haas J, Meder B, Sørensen KE, van Oort RJ, Mogensen J, Hubner N, Creemers EE, van der Velden J, Pinto YM. Beqqali A, et al. Cardiovasc Res. 2016 Oct;112(1):452-63. doi: 10.1093/cvr/cvw192. Epub 2016 Aug 5. Cardiovasc Res. 2016. PMID: 27496873
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