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Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress.
Schug ZT, Peck B, Jones DT, Zhang Q, Grosskurth S, Alam IS, Goodwin LM, Smethurst E, Mason S, Blyth K, McGarry L, James D, Shanks E, Kalna G, Saunders RE, Jiang M, Howell M, Lassailly F, Thin MZ, Spencer-Dene B, Stamp G, van den Broek NJ, Mackay G, Bulusu V, Kamphorst JJ, Tardito S, Strachan D, Harris AL, Aboagye EO, Critchlow SE, Wakelam MJ, Schulze A, Gottlieb E. Schug ZT, et al. Among authors: van den broek nj. Cancer Cell. 2015 Jan 12;27(1):57-71. doi: 10.1016/j.ccell.2014.12.002. Cancer Cell. 2015. PMID: 25584894 Free PMC article.
Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis.
Cardaci S, Zheng L, MacKay G, van den Broek NJ, MacKenzie ED, Nixon C, Stevenson D, Tumanov S, Bulusu V, Kamphorst JJ, Vazquez A, Fleming S, Schiavi F, Kalna G, Blyth K, Strathdee D, Gottlieb E. Cardaci S, et al. Among authors: van den broek nj. Nat Cell Biol. 2015 Oct;17(10):1317-26. doi: 10.1038/ncb3233. Epub 2015 Aug 24. Nat Cell Biol. 2015. PMID: 26302408 Free PMC article.
Serine one-carbon catabolism with formate overflow.
Meiser J, Tumanov S, Maddocks O, Labuschagne CF, Athineos D, Van Den Broek N, Mackay GM, Gottlieb E, Blyth K, Vousden K, Kamphorst JJ, Vazquez A. Meiser J, et al. Sci Adv. 2016 Oct 28;2(10):e1601273. doi: 10.1126/sciadv.1601273. eCollection 2016 Oct. Sci Adv. 2016. PMID: 27819051 Free PMC article.
Analysis of Cell Metabolism Using LC-MS and Isotope Tracers.
Mackay GM, Zheng L, van den Broek NJ, Gottlieb E. Mackay GM, et al. Among authors: van den broek nj. Methods Enzymol. 2015;561:171-96. doi: 10.1016/bs.mie.2015.05.016. Epub 2015 Aug 17. Methods Enzymol. 2015. PMID: 26358905 Review.
Modulating the therapeutic response of tumours to dietary serine and glycine starvation.
Maddocks ODK, Athineos D, Cheung EC, Lee P, Zhang T, van den Broek NJF, Mackay GM, Labuschagne CF, Gay D, Kruiswijk F, Blagih J, Vincent DF, Campbell KJ, Ceteci F, Sansom OJ, Blyth K, Vousden KH. Maddocks ODK, et al. Among authors: van den broek njf. Nature. 2017 Apr 19;544(7650):372-376. doi: 10.1038/nature22056. Nature. 2017. PMID: 28425994 Free article.
Resistance to BRAF inhibitors induces glutamine dependency in melanoma cells.
Baenke F, Chaneton B, Smith M, Van Den Broek N, Hogan K, Tang H, Viros A, Martin M, Galbraith L, Girotti MR, Dhomen N, Gottlieb E, Marais R. Baenke F, et al. Mol Oncol. 2016 Jan;10(1):73-84. doi: 10.1016/j.molonc.2015.08.003. Epub 2015 Aug 20. Mol Oncol. 2016. PMID: 26365896 Free PMC article.
35 results