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Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism.
Koenis DS, Medzikovic L, van Loenen PB, van Weeghel M, Huveneers S, Vos M, Evers-van Gogh IJ, Van den Bossche J, Speijer D, Kim Y, Wessels L, Zelcer N, Zwart W, Kalkhoven E, de Vries CJ. Koenis DS, et al. Among authors: van weeghel m, van den bossche j, van loenen pb. Cell Rep. 2018 Aug 21;24(8):2127-2140.e7. doi: 10.1016/j.celrep.2018.07.065. Cell Rep. 2018. PMID: 30134173 Free PMC article.
A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia.
Baardman J, Verberk SGS, Prange KHM, van Weeghel M, van der Velden S, Ryan DG, Wüst RCI, Neele AE, Speijer D, Denis SW, Witte ME, Houtkooper RH, O'neill LA, Knatko EV, Dinkova-Kostova AT, Lutgens E, de Winther MPJ, Van den Bossche J. Baardman J, et al. Among authors: van weeghel m, van den bossche j, van der velden s. Cell Rep. 2018 Nov 20;25(8):2044-2052.e5. doi: 10.1016/j.celrep.2018.10.092. Cell Rep. 2018. PMID: 30463003 Free article.
A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways.
Molenaars M, Janssens GE, Williams EG, Jongejan A, Lan J, Rabot S, Joly F, Moerland PD, Schomakers BV, Lezzerini M, Liu YJ, McCormick MA, Kennedy BK, van Weeghel M, van Kampen AHC, Aebersold R, MacInnes AW, Houtkooper RH. Molenaars M, et al. Among authors: van weeghel m, van kampen ahc. Cell Metab. 2020 Mar 3;31(3):549-563.e7. doi: 10.1016/j.cmet.2020.01.011. Epub 2020 Feb 20. Cell Metab. 2020. PMID: 32084377 Free PMC article.
Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism.
Loregger A, Raaben M, Nieuwenhuis J, Tan JME, Jae LT, van den Hengel LG, Hendrix S, van den Berg M, Scheij S, Song JY, Huijbers IJ, Kroese LJ, Ottenhoff R, van Weeghel M, van de Sluis B, Brummelkamp T, Zelcer N. Loregger A, et al. Among authors: van weeghel m, van den hengel lg, van den berg m, van de sluis b. Nat Commun. 2020 Feb 28;11(1):1128. doi: 10.1038/s41467-020-14811-1. Nat Commun. 2020. PMID: 32111832 Free PMC article.
Succinate Is an Inflammation-Induced Immunoregulatory Metabolite in Macrophages.
Harber KJ, de Goede KE, Verberk SGS, Meinster E, de Vries HE, van Weeghel M, de Winther MPJ, Van den Bossche J. Harber KJ, et al. Among authors: van weeghel m, van den bossche j. Metabolites. 2020 Sep 15;10(9):372. doi: 10.3390/metabo10090372. Metabolites. 2020. PMID: 32942769 Free PMC article.
Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques.
Baardman J, Verberk SGS, van der Velden S, Gijbels MJJ, van Roomen CPPA, Sluimer JC, Broos JY, Griffith GR, Prange KHM, van Weeghel M, Lakbir S, Molenaar D, Meinster E, Neele AE, Kooij G, de Vries HE, Lutgens E, Wellen KE, de Winther MPJ, Van den Bossche J. Baardman J, et al. Among authors: van weeghel m, van den bossche j, van der velden s, van roomen cppa. Nat Commun. 2020 Dec 8;11(1):6296. doi: 10.1038/s41467-020-20141-z. Nat Commun. 2020. PMID: 33293558 Free PMC article.
d-2-Hydroxyglutarate is an anti-inflammatory immunometabolite that accumulates in macrophages after TLR4 activation.
de Goede KE, Harber KJ, Gorki FS, Verberk SGS, Groh LA, Keuning ED, Struys EA, van Weeghel M, Haschemi A, de Winther MPJ, van Dierendonck XAMH, Van den Bossche J. de Goede KE, et al. Among authors: van weeghel m, van den bossche j, van dierendonck xamh. Biochim Biophys Acta Mol Basis Dis. 2022 Sep 1;1868(9):166427. doi: 10.1016/j.bbadis.2022.166427. Epub 2022 May 6. Biochim Biophys Acta Mol Basis Dis. 2022. PMID: 35526742 Free article.
Anti-retroviral treatment with zidovudine alters pyrimidine metabolism, reduces translation, and extends healthy longevity via ATF-4.
McIntyre RL, Molenaars M, Schomakers BV, Gao AW, Kamble R, Jongejan A, van Weeghel M, van Kuilenburg ABP, Possemato R, Houtkooper RH, Janssens GE. McIntyre RL, et al. Among authors: van weeghel m, van kuilenburg abp. Cell Rep. 2023 Jan 31;42(1):111928. doi: 10.1016/j.celrep.2022.111928. Epub 2022 Dec 30. Cell Rep. 2023. PMID: 36640360 Free article.
93 results