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TGFβ-mediated expression of TGFβ-activating integrins in SSc monocytes: disturbed activation of latent TGFβ?
van Caam A, Aarts J, van Ee T, Vitters E, Koenders M, van de Loo F, van Lent P, van den Hoogen F, Thurlings R, Vonk MC, van der Kraan PM. van Caam A, et al. Among authors: van der kraan pm, van de loo f, van lent p, van den hoogen f, van ee t. Arthritis Res Ther. 2020 Mar 6;22(1):42. doi: 10.1186/s13075-020-2130-5. Arthritis Res Ther. 2020. PMID: 32143707 Free PMC article.
Identification of Transcription Factors Responsible for a Transforming Growth Factor-β-Driven Hypertrophy-like Phenotype in Human Osteoarthritic Chondrocytes.
Thielen NGM, Neefjes M, Vitters EL, van Beuningen HM, Blom AB, Koenders MI, van Lent PLEM, van de Loo FAJ, Blaney Davidson EN, van Caam APM, van der Kraan PM. Thielen NGM, et al. Among authors: van caam apm. Cells. 2022 Apr 5;11(7):1232. doi: 10.3390/cells11071232. Cells. 2022. PMID: 35406794 Free PMC article.
Separating friend from foe: Inhibition of TGF-β-induced detrimental SMAD1/5/9 phosphorylation while maintaining protective SMAD2/3 signaling in OA chondrocytes.
Thielen NGM, van Caam APM, V Beuningen HM, Vitters EL, van den Bosch MHJ, Koenders MI, van de Loo FAJ, Blaney Davidson EN, van der Kraan PM. Thielen NGM, et al. Among authors: van caam apm. Osteoarthritis Cartilage. 2023 Nov;31(11):1481-1490. doi: 10.1016/j.joca.2023.08.004. Epub 2023 Aug 29. Osteoarthritis Cartilage. 2023. PMID: 37652257 Free article.
IL37 dampens the IL1β-induced catabolic status of human OA chondrocytes.
van Geffen EW, van Caam AP, van Beuningen HM, Vitters EL, Schreurs W, van de Loo FA, van Lent PL, Koenders MI, Blaney Davidson EN, van der Kraan PM. van Geffen EW, et al. Among authors: van der kraan pm, van lent pl, van de loo fa, van caam ap, van beuningen hm. Rheumatology (Oxford). 2017 Mar 1;56(3):351-361. doi: 10.1093/rheumatology/kew411. Rheumatology (Oxford). 2017. PMID: 27940589
Increased IL-6 receptor expression and signaling in ageing cartilage can be explained by loss of TGF-β-mediated IL-6 receptor suppression.
Wiegertjes R, Thielen NGM, van Caam APM, van Laar M, van Beuningen HM, Koenders MI, van Lent PLEM, van der Kraan PM, van de Loo FAJ, Blaney Davidson EN. Wiegertjes R, et al. Among authors: van laar m, van der kraan pm, van de loo faj, van caam apm, van beuningen hm, van lent plem. Osteoarthritis Cartilage. 2021 May;29(5):773-782. doi: 10.1016/j.joca.2021.01.008. Epub 2021 Feb 20. Osteoarthritis Cartilage. 2021. PMID: 33617971 Free article.
Osteoarthritis-Related Inflammation Blocks TGF-β's Protective Effect on Chondrocyte Hypertrophy via (de)Phosphorylation of the SMAD2/3 Linker Region.
Thielen N, Neefjes M, Wiegertjes R, van den Akker G, Vitters E, van Beuningen H, Blaney Davidson E, Koenders M, van Lent P, van de Loo F, van Caam A, van der Kraan P. Thielen N, et al. Among authors: van beuningen h, van de loo f, van lent p, van den akker g, van caam a, van der kraan p. Int J Mol Sci. 2021 Jul 29;22(15):8124. doi: 10.3390/ijms22158124. Int J Mol Sci. 2021. PMID: 34360888 Free PMC article.
Cripto favors chondrocyte hypertrophy via TGF-β SMAD1/5 signaling during development of osteoarthritis.
Garcia de Vinuesa A, Sanchez-Duffhues G, Blaney-Davidson E, van Caam A, Lodder K, Ramos Y, Kloppenburg M, Meulenbelt I, van der Kraan P, Goumans MJ, Ten Dijke P. Garcia de Vinuesa A, et al. Among authors: van caam a, van der kraan p. J Pathol. 2021 Nov;255(3):330-342. doi: 10.1002/path.5774. Epub 2021 Sep 6. J Pathol. 2021. PMID: 34357595 Free PMC article.
36 results