Cleavage of the Jaw1 C-terminal region enhances its augmentative effect on the Ca2+ release via IP3 receptors.
Kozono T, Jogano C, Okumura W, Sato H, Matsui H, Takagi T, Okumura N, Takao T, Tonozuka T, Nishikawa A.
Kozono T, et al.
J Cell Sci. 2023 Feb 15;136(4):jcs260439. doi: 10.1242/jcs.260439. Epub 2023 Feb 15.
J Cell Sci. 2023.
PMID: 36789796
Jaw1 (also known as IRAG2), a tail-anchored protein with 39 carboxyl (C)-terminal amino acids, is oriented to the lumen of the endoplasmic reticulum and outer nuclear membrane. We previously reported that Jaw1, as a member of the KASH protein family, plays a role in …
Jaw1 (also known as IRAG2), a tail-anchored protein with 39 carboxyl (C)-terminal amino acids, is oriented to the lumen of the endoplasmic r …