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Livin is involved in TGF-beta1-induced renal tubular epithelial-mesenchymal transition through lncRNA-ATB.
Zhou J, Jiang H. Zhou J, et al. Ann Transl Med. 2019 Sep;7(18):463. doi: 10.21037/atm.2019.08.29. Ann Transl Med. 2019. PMID: 31700899 Free PMC article.
METHODS: We confirmed that Livin and lncRNA-ATB could aggravate EMT in vivo and in vitro, lncRNA-ATB could be suppressed by the silencing of Livin whereas Livin expression was nearly stable when lncRNA-ATB was overexpressed or knocked out. RESULTS: Livin …
METHODS: We confirmed that Livin and lncRNA-ATB could aggravate EMT in vivo and in vitro, lncRNA-ATB could be suppressed by the silen …
Livin promotes colon cancer progression by regulation of H2A.X(Y39ph) via JMJD6.
Ge Y, Liu BL, Cui JP, Li SQ. Ge Y, et al. Life Sci. 2019 Oct 1;234:116788. doi: 10.1016/j.lfs.2019.116788. Epub 2019 Aug 22. Life Sci. 2019. PMID: 31445935
Livin is an important member of the human inhibitor of apoptosis proteins (IAPs) family. IAPs are proteins with antiapoptotic abilities, and their functions are different from the Bcl-2 (B-cell lymphoma-2) family proteins. However, the precise role of Livin in colon …
Livin is an important member of the human inhibitor of apoptosis proteins (IAPs) family. IAPs are proteins with antiapoptotic abiliti …
Livin Regulates H2A.X(Y142) Phosphorylation and Promotes Autophagy in Colon Cancer Cells via a Novel Kinase Activity.
Ge Y, Liu BL, Cui JP, Li SQ. Ge Y, et al. Front Oncol. 2019 Nov 14;9:1233. doi: 10.3389/fonc.2019.01233. eCollection 2019. Front Oncol. 2019. PMID: 31799193 Free PMC article.
H2A.X-/-Livin+/+ SW480 cells were co-transfected with H2A.X(WT)/H2A.X(Y142F) plasmid and LC3 EGFP-tagged plasmid to explore whether H2A.X(Y142F) was involved in Livin-mediated autophagy induced by starvation in colon cancer cells. ...In vitro kinase assay confirmed …
H2A.X-/-Livin+/+ SW480 cells were co-transfected with H2A.X(WT)/H2A.X(Y142F) plasmid and LC3 EGFP-tagged plasmid to explore whether H …
miR-198-induced upregulation of Livin may be associated with the prognosis and contribute to the oncogenesis of lung adenocarcinoma.
Liang Y, Wang H, Sun Y, Chen S, Wang H, Huang R, Zhao X, Fu W, Yang C. Liang Y, et al. Oncol Rep. 2017 Oct;38(4):2096-2104. doi: 10.3892/or.2017.5866. Epub 2017 Aug 1. Oncol Rep. 2017. PMID: 28765921 Free PMC article.
The overexpression of Livin is partly caused by the downregulation of miR-198. Further exploration revealed that miRNA-198-mediated silencing of Livin significantly inhibited cell growth and enhanced apoptosis of A549 cells, accompanied by marked upregulation of cas …
The overexpression of Livin is partly caused by the downregulation of miR-198. Further exploration revealed that miRNA-198-mediated s …
Livin promotes the progression and metastasis of breast cancer through the regulation of epithelial-mesenchymal transition via the p38/GSK3beta pathway.
Han Y, Zhang L, Wang W, Li J, Song M. Han Y, et al. Oncol Rep. 2017 Dec;38(6):3574-3582. doi: 10.3892/or.2017.6017. Epub 2017 Oct 10. Oncol Rep. 2017. PMID: 29039608
However, the role of Livin in EMT and metastasis of breast cancer and its underlying mechanisms are not fully elucidated. ...Conversely, the downregulation of Livin had the opposite effect in MDA-MB-231 cells. Furthermore, the upregulation of Livin expression …
However, the role of Livin in EMT and metastasis of breast cancer and its underlying mechanisms are not fully elucidated. ...Converse …
Overexpression of Livin promotes migration and invasion of colorectal cancer cells by induction of epithelial-mesenchymal transition via NF-kappaB activation.
Ge Y, Cao X, Wang D, Sun W, Sun H, Han B, Cui J, Liu B. Ge Y, et al. Onco Targets Ther. 2016 Feb 29;9:1011-21. doi: 10.2147/OTT.S93738. eCollection 2016. Onco Targets Ther. 2016. PMID: 27013894 Free PMC article.
Concurrently, the inhibition of Livin reduces the proliferation, migration, and invasion of HCT116 cells. ...Livin may be a potential therapeutic target for CRC....
Concurrently, the inhibition of Livin reduces the proliferation, migration, and invasion of HCT116 cells. ...Livin may be a po …
Down-regulation of lncRNA DNAJC3-AS1 inhibits colon cancer via regulating miR-214-3p/LIVIN axis.
Han B, Ge Y, Cui J, Liu B. Han B, et al. Bioengineered. 2020 Dec;11(1):524-535. doi: 10.1080/21655979.2020.1757224. Bioengineered. 2020. PMID: 32352854 Free PMC article.
Moreover, miR-214-3p can bind to DNAJC3-AS1, and knockdown of DNAJC3-AS1 increased miR-214-3p expression in colon cancer cells. LIVIN was identified as a target of miR-214-3p. The up-regulation of miR-214-3p inhibited the protein expression of LIVIN and suppressed t …
Moreover, miR-214-3p can bind to DNAJC3-AS1, and knockdown of DNAJC3-AS1 increased miR-214-3p expression in colon cancer cells. LIVIN …
Livin may serve as a marker for prognosis of bladder cancer relapse and a target of bladder cancer treatment.
Liu HB, Kong CZ, Zeng Y, Liu XK, Bi JB, Jiang YJ, Han S. Liu HB, et al. Urol Oncol. 2009 May-Jun;27(3):277-83. doi: 10.1016/j.urolonc.2008.03.015. Epub 2008 Jun 16. Urol Oncol. 2009. PMID: 18555709
OBJECTIVES: To evaluate the expression of Livin in bladder cancer, investigate its clinical and prognostic implications, and explore the effect of gene Livin transfection on the proliferation and apoptosis in bladder cancer cells. ...The positive rate of Livinalpha …
OBJECTIVES: To evaluate the expression of Livin in bladder cancer, investigate its clinical and prognostic implications, and explore …
Effects of RNA interference-mediated knockdown of livin and survivin using monomethoxypolyethylene glycol-chitosan nanoparticles in MG-63 osteosarcoma cells.
Guan HP, Sun JZ, Feng XL, Chen JS, Chen FJ, Cheng XF, Liu XW, Ni B. Guan HP, et al. Mol Med Rep. 2016 Feb;13(2):1821-6. doi: 10.3892/mmr.2015.4709. Epub 2015 Dec 23. Mol Med Rep. 2016. PMID: 26708654
The apoptosis-inducing effects of livin and surivin knockdown were investigated using a Hoechst staining kit. ...Thus the results indicate a synergistic effect of livin and survivin....
The apoptosis-inducing effects of livin and surivin knockdown were investigated using a Hoechst staining kit. ...Thus the results ind …
RNA interference-mediated knockdown of Livin suppresses cell proliferation and invasion and enhances the chemosensitivity to cisplatin in human osteosarcoma cells.
Li X, Fan S, Li L, Wang L, Fan G, Zhao Q, Li Y. Li X, et al. Int J Oncol. 2013 Jul;43(1):159-68. doi: 10.3892/ijo.2013.1925. Epub 2013 Apr 30. Int J Oncol. 2013. PMID: 23632777
However, the potential roles of Livin in tumorigenesis have not been elucidated. In the present study, we employed RNA interference (RNAi) technology to suppress endogenous Livin expression in osteosarcoma cells and successfully generated a U2-OS cell line with stab …
However, the potential roles of Livin in tumorigenesis have not been elucidated. In the present study, we employed RNA interference ( …
17 results