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Long-term expanding human airway organoids for disease modeling.
Sachs N, Papaspyropoulos A, Zomer-van Ommen DD, Heo I, Böttinger L, Klay D, Weeber F, Huelsz-Prince G, Iakobachvili N, Amatngalim GD, de Ligt J, van Hoeck A, Proost N, Viveen MC, Lyubimova A, Teeven L, Derakhshan S, Korving J, Begthel H, Dekkers JF, Kumawat K, Ramos E, van Oosterhout MF, Offerhaus GJ, Wiener DJ, Olimpio EP, Dijkstra KK, Smit EF, van der Linden M, Jaksani S, van de Ven M, Jonkers J, Rios AC, Voest EE, van Moorsel CH, van der Ent CK, Cuppen E, van Oudenaarden A, Coenjaerts FE, Meyaard L, Bont LJ, Peters PJ, Tans SJ, van Zon JS, Boj SF, Vries RG, Beekman JM, Clevers H. Sachs N, et al. Among authors: de ligt j. EMBO J. 2019 Feb 15;38(4):e100300. doi: 10.15252/embj.2018100300. Epub 2019 Jan 14. EMBO J. 2019. PMID: 30643021 Free PMC article.
A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity.
Sachs N, de Ligt J, Kopper O, Gogola E, Bounova G, Weeber F, Balgobind AV, Wind K, Gracanin A, Begthel H, Korving J, van Boxtel R, Duarte AA, Lelieveld D, van Hoeck A, Ernst RF, Blokzijl F, Nijman IJ, Hoogstraat M, van de Ven M, Egan DA, Zinzalla V, Moll J, Boj SF, Voest EE, Wessels L, van Diest PJ, Rottenberg S, Vries RGJ, Cuppen E, Clevers H. Sachs N, et al. Among authors: de ligt j. Cell. 2018 Jan 11;172(1-2):373-386.e10. doi: 10.1016/j.cell.2017.11.010. Epub 2017 Dec 7. Cell. 2018. PMID: 29224780 Free article.
Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids.
Fumagalli A, Drost J, Suijkerbuijk SJ, van Boxtel R, de Ligt J, Offerhaus GJ, Begthel H, Beerling E, Tan EH, Sansom OJ, Cuppen E, Clevers H, van Rheenen J. Fumagalli A, et al. Among authors: de ligt j. Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):E2357-E2364. doi: 10.1073/pnas.1701219114. Epub 2017 Mar 7. Proc Natl Acad Sci U S A. 2017. PMID: 28270604 Free PMC article.
Long-term culture of genome-stable bipotent stem cells from adult human liver.
Huch M, Gehart H, van Boxtel R, Hamer K, Blokzijl F, Verstegen MM, Ellis E, van Wenum M, Fuchs SA, de Ligt J, van de Wetering M, Sasaki N, Boers SJ, Kemperman H, de Jonge J, Ijzermans JN, Nieuwenhuis EE, Hoekstra R, Strom S, Vries RR, van der Laan LJ, Cuppen E, Clevers H. Huch M, et al. Among authors: de jonge j, de ligt j. Cell. 2015 Jan 15;160(1-2):299-312. doi: 10.1016/j.cell.2014.11.050. Epub 2014 Dec 18. Cell. 2015. PMID: 25533785 Free PMC article.
Tissue-specific mutation accumulation in human adult stem cells during life.
Blokzijl F, de Ligt J, Jager M, Sasselli V, Roerink S, Sasaki N, Huch M, Boymans S, Kuijk E, Prins P, Nijman IJ, Martincorena I, Mokry M, Wiegerinck CL, Middendorp S, Sato T, Schwank G, Nieuwenhuis EE, Verstegen MM, van der Laan LJ, de Jonge J, IJzermans JN, Vries RG, van de Wetering M, Stratton MR, Clevers H, Cuppen E, van Boxtel R. Blokzijl F, et al. Among authors: de jonge j, de ligt j. Nature. 2016 Oct 13;538(7624):260-264. doi: 10.1038/nature19768. Epub 2016 Oct 3. Nature. 2016. PMID: 27698416 Free PMC article.
Toward effective software solutions for big biology.
Prins P, de Ligt J, Tarasov A, Jansen RC, Cuppen E, Bourne PE. Prins P, et al. Among authors: de ligt j. Nat Biotechnol. 2015 Jul;33(7):686-7. doi: 10.1038/nbt.3240. Nat Biotechnol. 2015. PMID: 26154002 No abstract available.
68 results