de Lau WB - Search Results

1

de Lau WB, Snel B, Clevers HC. de Lau WB, et al. Genome Biol. 2012;13(3):242. doi: 10.1186/gb-2012-13-3-242. Genome Biol. 2012. PMID: 22439850 Free PMC article. Review.

2

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.

de Lau W, Barker N, Low TY, Koo BK, Li VS, Teunissen H, Kujala P, Haegebarth A, Peters PJ, van de Wetering M, Stange DE, van Es JE, Guardavaccaro D, Schasfoort RB, Mohri Y, Nishimori K, Mohammed S, Heck AJ, Clevers H. de Lau W, et al. Nature. 2011 Jul 4;476(7360):293-7. doi: 10.1038/nature10337. Nature. 2011. PMID: 21727895

3

Structures of Wnt-antagonist ZNRF3 and its complex with R-spondin 1 and implications for signaling.

Peng WC, de Lau W, Madoori PK, Forneris F, Granneman JC, Clevers H, Gros P. Peng WC, et al. PLoS One. 2013 Dec 12;8(12):e83110. doi: 10.1371/journal.pone.0083110. eCollection 2013. PLoS One. 2013. PMID: 24349440 Free PMC article.

4

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength.

de Lau W, Peng WC, Gros P, Clevers H. de Lau W, et al. Genes Dev. 2014 Feb 15;28(4):305-16. doi: 10.1101/gad.235473.113. Genes Dev. 2014. PMID: 24532711 Free PMC article. Review.

5

WNT signaling in the normal intestine and colorectal cancer.

de Lau W, Barker N, Clevers H. de Lau W, et al. Front Biosci. 2007 Jan 1;12:471-91. doi: 10.2741/2076. Front Biosci. 2007. PMID: 17127311 Review.

6

Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts".

de Lau W, Kujala P, Schneeberger K, Middendorp S, Li VS, Barker N, Martens A, Hofhuis F, DeKoter RP, Peters PJ, Nieuwenhuis E, Clevers H. de Lau W, et al. Mol Cell Biol. 2012 Sep;32(18):3639-47. doi: 10.1128/MCB.00434-12. Epub 2012 Jul 9. Mol Cell Biol. 2012. PMID: 22778137 Free PMC article.

7

Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5.

Peng WC, de Lau W, Forneris F, Granneman JC, Huch M, Clevers H, Gros P. Peng WC, et al. Cell Rep. 2013 Jun 27;3(6):1885-92. doi: 10.1016/j.celrep.2013.06.009. Cell Rep. 2013. PMID: 23809763 Free article.

8

Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins.

van Andel H, Ren Z, Koopmans I, Joosten SP, Kocemba KA, de Lau W, Kersten MJ, de Bruin AM, Guikema JE, Clevers H, Spaargaren M, Pals ST. van Andel H, et al. Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):376-381. doi: 10.1073/pnas.1618650114. Epub 2016 Dec 27. Proc Natl Acad Sci U S A. 2017. PMID: 28028233 Free PMC article.

9

Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling.

Janda CY, Dang LT, You C, Chang J, de Lau W, Zhong ZA, Yan KS, Marecic O, Siepe D, Li X, Moody JD, Williams BO, Clevers H, Piehler J, Baker D, Kuo CJ, Garcia KC. Janda CY, et al. Nature. 2017 May 11;545(7653):234-237. doi: 10.1038/nature22306. Epub 2017 May 3. Nature. 2017. PMID: 28467818 Free PMC article.

10

Syndecan-1 promotes Wnt/β-catenin signaling in multiple myeloma by presenting Wnts and R-spondins.

Ren Z, van Andel H, de Lau W, Hartholt RB, Maurice MM, Clevers H, Kersten MJ, Spaargaren M, Pals ST. Ren Z, et al. Blood. 2018 Mar 1;131(9):982-994. doi: 10.1182/blood-2017-07-797050. Epub 2017 Dec 6. Blood. 2018. PMID: 29212806 Free article.

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