de Kok TM - Search Results

1

Unravelling Mechanisms of Doxorubicin-Induced Toxicity in 3D Human Intestinal Organoids.

Rodrigues D, Coyle L, Füzi B, Ferreira S, Jo H, Herpers B, Chung SW, Fisher C, Kleinjans JCS, Jennen D, de Kok TM. Rodrigues D, et al. Among authors: de kok tm. Int J Mol Sci. 2022 Jan 24;23(3):1286. doi: 10.3390/ijms23031286. Int J Mol Sci. 2022. PMID: 35163210 Free PMC article.

2

New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids.

Rodrigues D, de Souza T, Coyle L, Di Piazza M, Herpers B, Ferreira S, Zhang M, Vappiani J, Sévin DC, Gabor A, Lynch A, Chung SW, Saez-Rodriguez J, Jennen DGJ, Kleinjans JCS, de Kok TM. Rodrigues D, et al. Among authors: de souza t, de kok tm. Arch Toxicol. 2021 Aug;95(8):2691-2718. doi: 10.1007/s00204-021-03092-2. Epub 2021 Jun 20. Arch Toxicol. 2021. PMID: 34151400 Free PMC article.

3

A Transcriptomic Approach to Elucidate the Mechanisms of Gefitinib-Induced Toxicity in Healthy Human Intestinal Organoids.

Rodrigues D, Herpers B, Ferreira S, Jo H, Fisher C, Coyle L, Chung SW, Kleinjans JCS, Jennen DGJ, de Kok TM. Rodrigues D, et al. Among authors: de kok tm. Int J Mol Sci. 2022 Feb 17;23(4):2213. doi: 10.3390/ijms23042213. Int J Mol Sci. 2022. PMID: 35216325 Free PMC article.

4

Global MicroRNA Analysis in Primary Hepatocyte Cultures.

Krauskopf J, Espín-Pérez A, Kleinjans JC, de Kok TM. Krauskopf J, et al. Among authors: de kok tm. Methods Mol Biol. 2015;1250:241-50. doi: 10.1007/978-1-4939-2074-7_17. Methods Mol Biol. 2015. PMID: 26272147

5

Drug-induced gene expression profile changes in relation to intestinal toxicity: State-of-the-art and new approaches.

Rodrigues D, Souza T, Jennen DGJ, Lemmens L, Kleinjans JCS, de Kok TM. Rodrigues D, et al. Among authors: de kok tm. Cancer Treat Rev. 2019 Jul;77:57-66. doi: 10.1016/j.ctrv.2019.06.004. Epub 2019 Jun 27. Cancer Treat Rev. 2019. PMID: 31279169 Free article. Review.

6

Gene expression responses reflecting 5-FU-induced toxicity: Comparison between patient colon tissue and 3D human colon organoids.

Rodrigues D, van Kampen R, van Bodegraven AA, Kleinjans JCS, Jennen DGJ, de Kok TM. Rodrigues D, et al. Among authors: de kok tm. Toxicol Lett. 2022 Dec 1;371:17-24. doi: 10.1016/j.toxlet.2022.09.013. Epub 2022 Sep 29. Toxicol Lett. 2022. PMID: 36183961 Free article.

7

'Omics analysis of low dose acetaminophen intake demonstrates novel response pathways in humans.

Jetten MJ, Gaj S, Ruiz-Aracama A, de Kok TM, van Delft JH, Lommen A, van Someren EP, Jennen DG, Claessen SM, Peijnenburg AA, Stierum RH, Kleinjans JC. Jetten MJ, et al. Among authors: de kok tm. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):320-8. doi: 10.1016/j.taap.2012.01.009. Epub 2012 Jan 20. Toxicol Appl Pharmacol. 2012. PMID: 22285215 Clinical Trial.

8

Pattern recognition methods to relate time profiles of gene expression with phenotypic data: a comparative study.

Hendrickx DM, Jennen DG, Briedé JJ, Cavill R, de Kok TM, Kleinjans JC. Hendrickx DM, et al. Among authors: de kok tm. Bioinformatics. 2015 Jul 1;31(13):2115-22. doi: 10.1093/bioinformatics/btv108. Epub 2015 Feb 19. Bioinformatics. 2015. PMID: 25701576

9

Human 3D multicellular microtissues: An upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity.

Jiang J, Messner S, Kelm JM, van Herwijnen M, Jennen DGJ, Kleinjans JC, de Kok TM. Jiang J, et al. Among authors: de kok tm. Toxicol Lett. 2019 Sep 15;312:34-44. doi: 10.1016/j.toxlet.2019.05.004. Epub 2019 May 3. Toxicol Lett. 2019. PMID: 31059760 Free article.

10

Development of novel tools for the in vitro investigation of drug-induced liver injury.

Jiang J, Wolters JE, van Breda SG, Kleinjans JC, de Kok TM. Jiang J, et al. Among authors: de kok tm. Expert Opin Drug Metab Toxicol. 2015;11(10):1523-37. doi: 10.1517/17425255.2015.1065814. Epub 2015 Jul 9. Expert Opin Drug Metab Toxicol. 2015. PMID: 26155718 Review.

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