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Novel S1P(1) receptor agonists--part 3: from thiophenes to pyridines.
Bolli MH, Abele S, Birker M, Bravo R, Bur D, de Kanter R, Kohl C, Grimont J, Hess P, Lescop C, Mathys B, Müller C, Nayler O, Rey M, Scherz M, Schmidt G, Seifert J, Steiner B, Velker J, Weller T. Bolli MH, et al. Among authors: de kanter r. J Med Chem. 2014 Jan 9;57(1):110-30. doi: 10.1021/jm4014696. Epub 2013 Dec 24. J Med Chem. 2014. PMID: 24367923
Novel S1P1 receptor agonists - Part 5: From amino-to alkoxy-pyridines.
Bolli MH, Lescop C, Birker M, de Kanter R, Hess P, Kohl C, Nayler O, Rey M, Sieber P, Velker J, Weller T, Steiner B. Bolli MH, et al. Among authors: de kanter r. Eur J Med Chem. 2016 Jun 10;115:326-41. doi: 10.1016/j.ejmech.2016.03.020. Epub 2016 Mar 12. Eur J Med Chem. 2016. PMID: 27027817
Discovery of a Potent, Selective T-type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies.
Bezençon O, Heidmann B, Siegrist R, Stamm S, Richard S, Pozzi D, Corminboeuf O, Roch C, Kessler M, Ertel EA, Reymond I, Pfeifer T, de Kanter R, Toeroek-Schafroth M, Moccia LG, Mawet J, Moon R, Rey M, Capeleto B, Fournier E. Bezençon O, et al. Among authors: de kanter r. J Med Chem. 2017 Dec 14;60(23):9769-9789. doi: 10.1021/acs.jmedchem.7b01236. Epub 2017 Nov 20. J Med Chem. 2017. PMID: 29116786
Structure-Activity Relationship, Drug Metabolism and Pharmacokinetics Properties Optimization, and in Vivo Studies of New Brain Penetrant Triple T-Type Calcium Channel Blockers.
Siegrist R, Pozzi D, Jacob G, Torrisi C, Colas K, Braibant B, Mawet J, Pfeifer T, de Kanter R, Roch C, Kessler M, Moon R, Corminboeuf O, Bezençon O. Siegrist R, et al. Among authors: de kanter r. J Med Chem. 2016 Dec 8;59(23):10661-10675. doi: 10.1021/acs.jmedchem.6b01356. Epub 2016 Nov 23. J Med Chem. 2016. PMID: 27933950
Macitentan does not interfere with hepatic bile salt transport.
Treiber A, Äänismaa P, de Kanter R, Delahaye S, Treher M, Hess P, Sidharta P. Treiber A, et al. Among authors: de kanter r. J Pharmacol Exp Ther. 2014 Jul;350(1):130-43. doi: 10.1124/jpet.114.214106. Epub 2014 Apr 25. J Pharmacol Exp Ther. 2014. PMID: 24769543 Free article. Clinical Trial.
54 results