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Dietary restriction: standing up for sirtuins.
Baur JA, Chen D, Chini EN, Chua K, Cohen HY, de Cabo R, Deng C, Dimmeler S, Gius D, Guarente LP, Helfand SL, Imai S, Itoh H, Kadowaki T, Koya D, Leeuwenburgh C, McBurney M, Nabeshima Y, Neri C, Oberdoerffer P, Pestell RG, Rogina B, Sadoshima J, Sartorelli V, Serrano M, Sinclair DA, Steegborn C, Tatar M, Tissenbaum HA, Tong Q, Tsubota K, Vaquero A, Verdin E. Baur JA, et al. Among authors: de cabo r. Science. 2010 Aug 27;329(5995):1012-3; author reply 1013-4. doi: 10.1126/science.329.5995.1012. Science. 2010. PMID: 20798296 Free PMC article. No abstract available.
Kaempferol increases levels of coenzyme Q in kidney cells and serves as a biosynthetic ring precursor.
Fernández-Del-Río L, Nag A, Gutiérrez Casado E, Ariza J, Awad AM, Joseph AI, Kwon O, Verdin E, de Cabo R, Schneider C, Torres JZ, Burón MI, Clarke CF, Villalba JM. Fernández-Del-Río L, et al. Among authors: de cabo r. Free Radic Biol Med. 2017 Sep;110:176-187. doi: 10.1016/j.freeradbiomed.2017.06.006. Epub 2017 Jun 9. Free Radic Biol Med. 2017. PMID: 28603085 Free PMC article.
A time to fast.
Di Francesco A, Di Germanio C, Bernier M, de Cabo R. Di Francesco A, et al. Among authors: de cabo r. Science. 2018 Nov 16;362(6416):770-775. doi: 10.1126/science.aau2095. Science. 2018. PMID: 30442801 Free PMC article. Review.
Models and Studies of Aging: Executive Summary of a Report from the U13 Conference Series.
Hurria A, Carpenter CR, McFarland F, Lundebjerg NE, de Cabo R, Ferrucci L, Studenski SA, Barzilai N, Briggs JP, Ix JH, Kitzman DW, Kuchel GA, Musi N, Newman JC, Rando TA, Smith AK, Walston JD, Kirkland JL, Yung R. Hurria A, et al. Among authors: de cabo r. J Am Geriatr Soc. 2019 Mar;67(3):428-433. doi: 10.1111/jgs.15788. Epub 2019 Jan 29. J Am Geriatr Soc. 2019. PMID: 30693953 Free PMC article.
ARDD 2020: from aging mechanisms to interventions.
Mkrtchyan GV, Abdelmohsen K, Andreux P, Bagdonaite I, Barzilai N, Brunak S, Cabreiro F, de Cabo R, Campisi J, Cuervo AM, Demaria M, Ewald CY, Fang EF, Faragher R, Ferrucci L, Freund A, Silva-García CG, Georgievskaya A, Gladyshev VN, Glass DJ, Gorbunova V, de Grey A, He WW, Hoeijmakers J, Hoffmann E, Horvath S, Houtkooper RH, Jensen MK, Jensen MB, Kane A, Kassem M, de Keizer P, Kennedy B, Karsenty G, Lamming DW, Lee KF, MacAulay N, Mamoshina P, Mellon J, Molenaars M, Moskalev A, Mund A, Niedernhofer L, Osborne B, Pak HH, Parkhitko A, Raimundo N, Rando TA, Rasmussen LJ, Reis C, Riedel CG, Franco-Romero A, Schumacher B, Sinclair DA, Suh Y, Taub PR, Toiber D, Treebak JT, Valenzano DR, Verdin E, Vijg J, Young S, Zhang L, Bakula D, Zhavoronkov A, Scheibye-Knudsen M. Mkrtchyan GV, et al. Among authors: de cabo r, de keizer p, de grey a. Aging (Albany NY). 2020 Dec 30;12(24):24484-24503. doi: 10.18632/aging.202454. Epub 2020 Dec 30. Aging (Albany NY). 2020. PMID: 33378272 Free PMC article. Review.
Membrane-bound CYB5R3 is a common effector of nutritional and oxidative stress response through FOXO3a and Nrf2.
Siendones E, SantaCruz-Calvo S, Martín-Montalvo A, Cascajo MV, Ariza J, López-Lluch G, Villalba JM, Acquaviva-Bourdain C, Roze E, Bernier M, de Cabo R, Navas P. Siendones E, et al. Among authors: de cabo r. Antioxid Redox Signal. 2014 Oct 20;21(12):1708-25. doi: 10.1089/ars.2013.5479. Epub 2014 Feb 28. Antioxid Redox Signal. 2014. PMID: 24450884 Free PMC article.
Are sirtuins viable targets for improving healthspan and lifespan?
Baur JA, Ungvari Z, Minor RK, Le Couteur DG, de Cabo R. Baur JA, et al. Among authors: de cabo r. Nat Rev Drug Discov. 2012 Jun 1;11(6):443-61. doi: 10.1038/nrd3738. Nat Rev Drug Discov. 2012. PMID: 22653216 Free PMC article. Review.
367 results