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Immune Checkpoint Blockade via PD-L1 Potentiates More CD28-Based than 4-1BB-Based Anti-Carbonic Anhydrase IX Chimeric Antigen Receptor T Cells.
de Campos NSP, de Oliveira Beserra A, Pereira PHB, Chaves AS, Fonseca FLA, da Silva Medina T, Dos Santos TG, Wang Y, Marasco WA, Suarez ER. de Campos NSP, et al. Among authors: da silva medina t. Int J Mol Sci. 2022 May 13;23(10):5448. doi: 10.3390/ijms23105448. Int J Mol Sci. 2022. PMID: 35628256 Free PMC article.
DNA hypomethylating agents increase activation and cytolytic activity of CD8+ T cells.
Loo Yau H, Bell E, Ettayebi I, de Almeida FC, Boukhaled GM, Shen SY, Allard D, Morancho B, Marhon SA, Ishak CA, Gonzaga IM, da Silva Medina T, Singhania R, Chakravarthy A, Chen R, Mehdipour P, Pommey S, Klein C, Amarante-Mendes GP, Roulois D, Arribas J, Stagg J, Brooks DG, De Carvalho DD. Loo Yau H, et al. Among authors: da silva medina t. Mol Cell. 2021 Apr 1;81(7):1469-1483.e8. doi: 10.1016/j.molcel.2021.01.038. Epub 2021 Feb 19. Mol Cell. 2021. PMID: 33609448 Free article.
Apoptotic cell-induced AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans.
Shinde R, Hezaveh K, Halaby MJ, Kloetgen A, Chakravarthy A, da Silva Medina T, Deol R, Manion KP, Baglaenko Y, Eldh M, Lamorte S, Wallace D, Chodisetti SB, Ravishankar B, Liu H, Chaudhary K, Munn DH, Tsirigos A, Madaio M, Gabrielsson S, Touma Z, Wither J, De Carvalho DD, McGaha TL. Shinde R, et al. Among authors: da silva medina t. Nat Immunol. 2018 Jun;19(6):571-582. doi: 10.1038/s41590-018-0107-1. Epub 2018 May 14. Nat Immunol. 2018. PMID: 29760532 Free PMC article.
Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells.
Lima-Fernandes E, Murison A, da Silva Medina T, Wang Y, Ma A, Leung C, Luciani GM, Haynes J, Pollett A, Zeller C, Duan S, Kreso A, Barsyte-Lovejoy D, Wouters BG, Jin J, Carvalho DD, Lupien M, Arrowsmith CH, O'Brien CA. Lima-Fernandes E, et al. Among authors: da silva medina t. Nat Commun. 2019 Mar 29;10(1):1436. doi: 10.1038/s41467-019-09309-4. Nat Commun. 2019. PMID: 30926792 Free PMC article.
Tertiary lymphoid structures as hubs of antitumour immunity.
Sarti Kinker G, da Silva Medina T. Sarti Kinker G, et al. Among authors: da silva medina t. Nat Rev Cancer. 2023 Dec;23(12):803. doi: 10.1038/s41568-023-00626-x. Nat Rev Cancer. 2023. PMID: 37758859 No abstract available.