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Synthesis of new N,S-acetal analogs derived from juglone with cytotoxic activity against Trypanossoma cruzi.
Pacheco PAF, de Menezes Ribeiro T, Dos Santos Galvão RM, Dos Santos EG, Faria AFM, von Ranke NL, Bello ML, Rodrigues CR, Ferreira VF, Souza ALA, de Jesús Hardoim D, da Silva Calabrese K, Faria RX, da Rocha DR. Pacheco PAF, et al. Among authors: da rocha dr, da silva calabrese k. J Bioenerg Biomembr. 2020 Jun;52(3):199-213. doi: 10.1007/s10863-020-09834-8. Epub 2020 May 17. J Bioenerg Biomembr. 2020. PMID: 32418003
Semisynthetic triterpenes led to the generation of selective antitrypanosomal lead compounds.
Guilhon-Simplicio F, Serrão CKR, Pinto ACDS, Pacheco PAF, Faria RX, da Rocha DR, Ferreira VF, Pereira-Junior RC, Matheeussen A, Baán A, Kiekens F, de Meneses Pereira M, Lima ES, Winter H, Cos P. Guilhon-Simplicio F, et al. Among authors: da rocha dr. Chem Biol Drug Des. 2022 Jun;99(6):868-883. doi: 10.1111/cbdd.14040. Epub 2022 Mar 31. Chem Biol Drug Des. 2022. PMID: 35313075
Antitumoral effect of novel synthetic 8-hydroxy-2-((4-nitrophenyl)thio)naphthalene-1,4-dione (CNN16) via ROS-mediated DNA damage, apoptosis and anti-migratory effect in colon cancer cell line.
da Silva EL, Mesquita FP, Ramos INF, Gomes CBSMR, Moreira CDS, Ferreira VF, da Rocha DR, Bahia MO, Moreira-Nunes CA, de Souza CRT, Burbano RMR, Montenegro RC. da Silva EL, et al. Among authors: da rocha dr. Toxicol Appl Pharmacol. 2022 Dec 1;456:116256. doi: 10.1016/j.taap.2022.116256. Epub 2022 Oct 5. Toxicol Appl Pharmacol. 2022. PMID: 36208702
Efficient Catalytic Oxidation of 3-Arylthio- and 3-Cyclohexylthio-lapachone Derivatives to New Sulfonyl Derivatives and Evaluation of Their Antibacterial Activities.
Cardoso MF, Gomes AT, Moreira CD, Simões MM, Neves MG, da Rocha DR, da Silva FC, Moreirinha C, Almeida A, Ferreira VF, Cavaleiro JA. Cardoso MF, et al. Among authors: da rocha dr, da silva fc. Molecules. 2017 Feb 16;22(2):302. doi: 10.3390/molecules22020302. Molecules. 2017. PMID: 28212345 Free PMC article.
28 results